ArticleEpilepsia open2018
Treatment of infantile spasms.
Article in Epilepsia open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06819670 (A Multicenter Pilot Clinical Trial to Prevent Infantile Spasms Relapse), which is not on this map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multicenter Pilot Clinical Trial to Prevent Infantile Spasms Relapse
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Outcomes following resective and disconnective strategies in the treatment of epileptic spasms: a systematic review of the literature and individual patient data meta-analysis.Frontiers in neurology · 2024Pooled it
- [Effect of prednisolone and adrenocorticotropic hormone in the treatment of infantile spasms: a Meta analysis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2019Pooled it
- Management of Infantile Epileptic Spasms Syndrome: A survey of US pediatric hospitals.Epilepsia open · 2026Article
- Cannabidiol reduces atypical absence seizures and epileptic spasms in a Gabrb3Epilepsia open · 2026Article
- Prediction of treatment response in infantile epileptic spasms syndrome using EEG phase-amplitude coupling.Epilepsia open · 2026Article
- Infantile epileptic spasms syndrome: Mechanisms and therapeutic approaches.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Review
- The acid-base balance homeostasis reflected by urine pH in children with infantile epileptic spasm syndrome may be associated with response to adrenocorticotropic hormone treatment: a retrospective cohort study.Translational pediatrics · 2025Article
- Adrenocorticotropic hormone combined with vigabatrin as a second-line therapy for West syndrome.Arquivos de neuro-psiquiatria · 2025Article
- Symptomatic vigabatrin-associated MRI toxicity is associated with simultaneous hormonal therapy among patients with infantile spasms.Epilepsia open · 2025Article
- Ketogenic drug tricaprilin (CER-0001) for the treatment of refractory infantile epileptic spasms: a phase 1/2a study.Frontiers in pediatrics · 2025Article
- Association of serum insulin-like growth factor-1 and adrenocorticotropic hormone therapeutic response in patients with infantile epileptic spasms syndrome.Frontiers in pharmacology · 2025Article
- Epileptic spasms relapse is associated with response latency but not conventional attributes of post-treatment EEG.Epilepsia open · 2024Article
- Initial combination versus early sequential standard therapies for Infantile Epileptic Spasms Syndrome-Feedback from stakeholders.Epilepsia open · 2024Article
- Treatment modalities for infantile spasms: current considerations and evolving strategies in clinical practice.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Review
- Hospital readmissions in children with new-onset infantile epileptic spasms syndrome.Epilepsia open · 2023Article
- Inequities in Therapy for Infantile Spasms: A Call to Action.Annals of neurology · 2022Article
- Multicenter Study of the Impact of COVID-19 Shelter-In-Place on Tertiary Hospital-based Care for Pediatric Neurologic Disease.The Neurohospitalist · 2022Article
- Trends and Costs Associated With the Diagnosis and Treatment of Infantile Spasms: A 10-Year Multicenter Retrospective Review.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2022Article
- Efficacy of Ketogenic Diet for Infantile Spasms in Chinese Patients With or Without Monogenic Etiology.Frontiers in pediatrics · 2022Article
- Vigabatrin-associated brain abnormalities on MRI in tuberous sclerosis complex patients with infantile spasms: are they preventable?Therapeutic advances in neurological disorders · 2022Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The treatment of infantile spasms is challenging, especially in the context of the following: (1) a severe phenotype with high morbidity and mortality; (2) the urgency of diagnosis and successful early response to therapy; and (3) the paucity of effective, safe, and well-tolerated therapies. Even after initially successful treatment, relapse risk is substantial and the most effective therapies pose considerable risk with long-term administration. In evaluating any treatment for infantile spasms, the key short-term outcome measure is freedom from both epileptic spasms and hypsarrhythmia. In contrast, the most important long-term outcomes are enduring seizure-freedom and measures of intellectual performance in later childhood and adulthood. First-line treatment options-namely hormonal therapy and vigabatrin-display moderate to high efficacy but also exhibit substantial side-effect burdens. Data on efficacy and safety of each class of therapy, as well as the combination of these therapies, are reviewed in detail. Specific hormonal therapies (adrenocorticotropic hormone and various corticosteroids) are contrasted. Those etiologies that prompt specific therapies are reviewed briefly, as are an array of second-line therapies supported by less-compelling data. The ketogenic diet is discussed in greater detail, with a focus on the limitations of numerous available studies that generally suggest that it is efficacious. Special discussion is allocated to cannabidiol-the investigational therapy that has received the most attention, and which is already in use in the form of various artisanal cannabis extracts. Finally, a treatment algorithm reflecting the concepts and controversies discussed in this review is presented.
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