Evidence map›Paper›PMID 30564636›Full record

ArticleNPJ precision oncology2018

Deep sequencing of circulating exosomal microRNA allows non-invasive glioblastoma diagnosis.

Saeideh Ebrahimkhani, Fatemeh Vafaee, Susannah Hallal, Heng Wei, Maggie Yuk T Lee, Paul E Young, Laveniya Satgunaseelan, Heidi Beadnall, Michael H Barnett, Brindha Shivalingam and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ precision oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  18. Current Understanding of the Exosomes and Their Associated Biomolecules in the Glioblastoma Biology, Clinical Treatment, and Diagnosis.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025
    Review
  19. Article
  20. Review

39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Saeideh Ebrahimkhani1Department of Neuropathology, Brainstorm Brain Cancer Research, Royal Prince Alfred Hospital, Camperdown, NSW Australia.
Fatemeh Vafaee3School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW Australia.ORCID 0000-0002-7521-2417
Susannah Hallal2Sydney Medical School, University of Sydney, Sydney, NSW Australia.
Heng Wei1Department of Neuropathology, Brainstorm Brain Cancer Research, Royal Prince Alfred Hospital, Camperdown, NSW Australia.
Maggie Yuk T Lee1Department of Neuropathology, Brainstorm Brain Cancer Research, Royal Prince Alfred Hospital, Camperdown, NSW Australia.
Paul E Young4Division of Molecular Structural and Computational Biology, Victor Chang Cardiac Research Institute, Sydney, NSW Australia.
Laveniya Satgunaseelan1Department of Neuropathology, Brainstorm Brain Cancer Research, Royal Prince Alfred Hospital, Camperdown, NSW Australia.
Heidi Beadnall6Department of Neurology, Royal Prince Alfred Hospital, Camperdown, Sydney, NSW Australia.
Michael H Barnett6Department of Neurology, Royal Prince Alfred Hospital, Camperdown, Sydney, NSW Australia.
Brindha Shivalingam7Department of Neurosurgery, Chris O'Brien Lifehouse, Sydney, NSW Australia.
Catherine M Suter4Division of Molecular Structural and Computational Biology, Victor Chang Cardiac Research Institute, Sydney, NSW Australia.
Michael E Buckland1Department of Neuropathology, Brainstorm Brain Cancer Research, Royal Prince Alfred Hospital, Camperdown, NSW Australia.
Kimberley L Kaufman1Department of Neuropathology, Brainstorm Brain Cancer Research, Royal Prince Alfred Hospital, Camperdown, NSW Australia.ORCID 0000-0002-7239-039X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosomes are nano-sized extracellular vesicles released by many cells that contain molecules characteristic of their cell of origin, including microRNA. Exosomes released by glioblastoma cross the blood-brain barrier into the peripheral circulation and carry molecular cargo distinct to that of "free-circulating" miRNA. In this pilot study, serum exosomal microRNAs were isolated from glioblastoma (

Identifiers

PMID30564636
PMCPMC6290767

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.