ArticleFrontiers in cellular and infection microbiology2018
Establishment and Development of Oral Microflora in 12-24 Month-Old Toddlers Monitored by High-Throughput Sequencing.
Article in Frontiers in cellular and infection microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Oral microbiota characteristics in children younger than 3 years with febrile seizures: a prospective observational study.BMC microbiology · 2026Observational
- Dysbiosis of Oral Microbiome: A Key Player in Oral Carcinogenesis? A Critical Review.Biomedicines · 2025Review
- Characterization of the unique oral microbiome of children harboringJournal of oral microbiology · 2024Article
- Impact of breastfeeding and other early-life factors on the development of the oral microbiome.Frontiers in microbiology · 2023Review
- Correlation between caries activity and salivary microbiota in preschool children.Frontiers in cellular and infection microbiology · 2023Article
- Salivary microbiome in children with Down syndrome: a case-control study.BMC oral health · 2022Article
- Study of oral microbiota diversity among groups of families originally from different countries.Saudi journal of biological sciences · 2022Article
- Maturation of the oral microbiota during primary teeth eruption: a longitudinal, preliminary study.Journal of oral microbiology · 2022Article
- Comparison of oral microbiome profiles in 18-month-old infants and their parents.Scientific reports · 2021Article
- Dynamic Observation of the Effect of Maternal Caries on the Oral Microbiota of Infants Aged 12-24 Months.Frontiers in cellular and infection microbiology · 2021Article
- The Clinical Potential of Oral Microbiota as a Screening Tool for Oral Squamous Cell Carcinomas.Frontiers in cellular and infection microbiology · 2021Article
- Microbial population shift and metabolic characterization of silver diamine fluoride treatment failure on dental caries.PloS one · 2021Article
- Maturation of the Oral Microbiome in Caries-Free Toddlers: A Longitudinal Study.Journal of dental research · 2020Article
- Acquisition, Divergence, and Personalization of the Female Perineal Microbiomes Are Driven by Developmental Milestones and Disrupted by Urinary Tract Infection: A Pilot Study.Frontiers in pediatrics · 2020Article
- Biogeography of the Oral Microbiome: The Site-Specialist Hypothesis.Annual review of microbiology · 2019Review
- Detection ofInternational journal of clinical pediatric dentistryArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A cohort study was conducted to evaluate oral microbial diversity among toddlers aged 12-24 months, and to describe the dynamic processes of colonization, development, and stabilization of the oral microflora during tooth eruption using high-throughput sequencing technology. A total of 20 healthy toddlers aged 12 months were included at baseline and followed up through 18-24 months. Clinical oral examinations of dental caries status and visible plaque index were carried out at three follow-up time points. Pooled supragingival plaque biofilm samples were also collected at ages 12, 18, and 24 months. Plaque biofilm DNA was extracted and analyzed by MiSeq sequencing. A total of 18 toddlers completed three follow-ups. At 12 months of age, all the toddlers only had eruption of the anterior teeth, without dental caries. At ages 18 and 24 months, one and two toddlers showed two and three teeth with carious white spots, respectively. Depth, Good's coverage, and sample size of sequencing were reasonable. The dominant bacterial genera in the oral cavity of 12-month-old toddlers were
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