ArticleTranslational vision science & technology2018
Enhanced Quantification of Retinal Perfusion by Improved Discrimination of Blood Flow From Bulk Motion Signal in OCTA.
Article in Translational vision science & technology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Widefield OCT angiography.Progress in retinal and eye research · 2025Review
- Optical coherence tomography angiography in neovascular age-related macular degeneration: comprehensive review of advancements and future perspective.Eye (London, England) · 2025Review
- Advances in OCT Angiography.Translational vision science & technology · 2025Review
- Astigmatism Influences Quantitative and Qualitative Analysis in Optical Coherence Tomography Angiography Imaging.Translational vision science & technology · 2024Article
- Optical coherence tomography angiography in diabetic retinopathy.Progress in retinal and eye research · 2023Review
- Artificial intelligence in OCT angiography.Progress in retinal and eye research · 2021Review
- Artifacts and artifact removal in optical coherence tomographic angiography.Quantitative imaging in medicine and surgery · 2021Review
- Plexus-specific retinal vascular anatomy and pathologies as seen by projection-resolved optical coherence tomographic angiography.Progress in retinal and eye research · 2021Review
- Real-time retinal layer segmentation of OCT volumes with GPU accelerated inferencing using a compressed, low-latency neural network.Biomedical optics express · 2020Article
- Sensorless adaptive-optics optical coherence tomographic angiography.Biomedical optics express · 2020Article
- Acute Hyperglycemia Reverses Neurovascular Coupling During Dark to Light Adaptation in Healthy Subjects on Optical Coherence Tomography Angiography.Investigative ophthalmology & visual science · 2020Article
- Quantitative optical coherence tomography angiography: A review.Experimental biology and medicine (Maywood, N.J.) · 2020Review
- Detecting and measuring areas of choriocapillaris low perfusion in intermediate, non-neovascular age-related macular degeneration.Neurophotonics · 2019Article
- Signal Strength Reduction Effects in OCT Angiography.Ophthalmology. Retina · 2019Article
- Three-dimensional structural and angiographic evaluation of foveal ischemia in diabetic retinopathy: method and validation.Biomedical optics express · 2019Article
- Automated detection of shadow artifacts in optical coherence tomography angiography.Biomedical optics express · 2019Article
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Authors and funding
6 authors.
Funding
Abstract
purposeQuantification of optical coherence tomography angiography (OCTA) is confounded by the prevalence of bulk motion. We have previously developed a regression-based bulk motion subtraction (rb-BMS) algorithm that estimates bulk motion velocity and corrects for its effect on flow signal. Here, we aim to investigate its ability to improve the reliability of capillary density (CD) quantification.
methodsTwo spectral-domain systems (70-kHz Avanti/AngioVue and 68-kHz Cirrus/AngioPlex) acquired 6 × 6-mm OCTA scans. The rb-BMS algorithm was applied on each OCTA volume. Regression analysis of angiographic versus reflectance signal of avascular A-lines in B-frames was used to set an optimized reflectance-adjusted threshold for discriminating vascular versus nonvascular voxels. The CD was calculated from en face maximum projections of the superficial vascular complex in macular scans and the nerve fiber layer plexus in disc scans, excluding large vessels. The retinal signal strength (RSS) was calculated by averaging the logarithmic-scale OCT reflectance signal, and its correlation with CD was investigated.
resultsEight healthy eyes were scanned with each instrument on 2 separate days. The rb-BMS algorithm improved within-visit repeatability and between-visit reproducibility of CD compared with a global-threshold measurement algorithm. Using the rb-BMS algorithm, the CD results were less affected by RSS and the population variation was reduced. Motion-induced line artifacts were also reduced.
conclusionsThe rb-BMS algorithm improved the reliability of perfusion quantification in OCTA on both Food and Drug Administration-cleared spectral-domain OCTA systems. TRANSLATIONAL RELEVANCE: The rb-BMS method helped reduce the inter-scan variability by generating accurate vessel maps, improving the reliability of retinal perfusion quantification.
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