Evidence map›Paper›PMID 30564440›Full record

ArticleEvolution letters2018

Evolution of longevity improves immunity in

Daniel K Fabian, Kathrin Garschall, Peter Klepsatel, Gonçalo Santos-Matos, Élio Sucena, Martin Kapun, Bruno Lemaitre, Christian Schlötterer, Robert Arking, Thomas Flatt

Open access · goldAbstract read
In one paragraph

Article in Evolution letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 82 citations in OpenAlex.

  1. Article
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  6. Age-Dependent Immune Defense AgainstJournal of fungi (Basel, Switzerland) · 2025
    Article
  7. Article
  8. Article
  9. Article
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  11. Protein Restriction Effects on Healthspan and Lifespan in Drosophila melanogaster Are Additive With a Longevity-Promoting Diet.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Studying the Geroprotective Properties of YAP/TAZ Signaling Inhibitors onInternational journal of molecular sciences · 2023
    Article
  16. Article
  17. Article
  18. Review
  19. Innate Immunity and Phenoptosis.Biochemistry. Biokhimiia · 2022
    Article
  20. Natural alleles at theProceedings. Biological sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 5 countries.

Daniel K FabianCentre for Pathogen Evolution, Department of Zoology University of Cambridge Cambridge United Kingdom.
Kathrin GarschallDepartment of Ecology and Evolution University of Lausanne Lausanne Switzerland.
Peter KlepsatelInstitut für Populationsgenetik Vetmeduni Vienna Vienna Austria.
Gonçalo Santos-MatosInstituto Gulbenkian de Ciência Oeiras Portugal.
Élio SucenaInstituto Gulbenkian de Ciência Oeiras Portugal.
Martin KapunDepartment of Ecology and Evolution University of Lausanne Lausanne Switzerland.
Bruno LemaitreGlobal Health Institute School of Life Sciences, EPFL Lausanne Switzerland.
Christian SchlöttererInstitut für Populationsgenetik Vetmeduni Vienna Vienna Austria.
Robert ArkingDepartment of Biological Sciences Wayne State University Detroit Michigan.
Thomas FlattInstitut für Populationsgenetik Vetmeduni Vienna Vienna Austria.ORCID https://orcid.org/0000-0002-5990-1503
University of Lausanne · CHÉcole Polytechnique Fédérale de Lausanne · CHInstituto Gulbenkian de Ciência · PTSlovak Academy of Sciences · SKUniversity of Cambridge · GBUniversity of Fribourg · CHUniversity of Lisbon · PTWayne State University · US

Funding

Austrian Science Fund FWF W 1225
6 · The paper itself

Abstract

Much has been learned about the genetics of aging from studies in model organisms, but still little is known about naturally occurring alleles that contribute to variation in longevity. For example, analysis of mutants and transgenes has identified insulin signaling as a major regulator of longevity, yet whether standing variation in this pathway underlies microevolutionary changes in lifespan and correlated fitness traits remains largely unclear. Here, we have analyzed the genomes of a set of

Indexed as

AgingDrosophila, evolveimmunitylongevityresequence

Identifiers

PMID30564440
PMCPMC6292704
OpenAlexW2901168199

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.