Evidence map›Paper›PMID 30564392›Full record

ArticleRoyal Society open science2018

Mutations in bacterial genes induce unanticipated changes in the relationship between bacterial pathogens in experimental otitis media.

Vinal Lakhani, Li Tan, Sayak Mukherjee, William C L Stewart, W Edward Swords, Jayajit Das

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Royal Society open science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Vinal LakhaniBattelle Center for Mathematical Medicine, The Research Institute at the Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.
Li TanDepartment of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, NC 27101, USA.
Sayak MukherjeeBattelle Center for Mathematical Medicine, The Research Institute at the Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.
William C L StewartBattelle Center for Mathematical Medicine, The Research Institute at the Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.
W Edward SwordsDepartment of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, NC 27101, USA.
Jayajit DasBattelle Center for Mathematical Medicine, The Research Institute at the Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.ORCID 0000-0001-9649-4698
Nationwide Children's Hospital · USUniversity of Alabama at Birmingham · USWake Forest University · US

Funding

Microbial interactions in otitis mediaR01DC010051 · NIDCD · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ORNELLES, DAVID ARNOLD, SWORDS, WILLIAM E · 2009 to 2018
$3.3M
Quantitative Determination of Ecological Niches for Polymicrobial Colonization inR01GM103612 · NIGMS · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI DAS, JAYAJIT · 2014 to 2017
$1.3M
NIDCD NIH HHS R01 DC010051NIGMS NIH HHS R01 GM103612
6 · The paper itself

Abstract

Otitis media (OM) is a common polymicrobial infection of the middle ear in children under the age of 15 years. A widely used experimental strategy to analyse roles of specific phenotypes of bacterial pathogens of OM is to study changes in co-infection kinetics of bacterial populations in animal models when a wild-type bacterial strain is replaced by a specific isogenic mutant strain in the co-inoculating mixtures. As relationships between the OM bacterial pathogens within the host are regulated by many interlinked processes, connecting the changes in the co-infection kinetics to a bacterial phenotype can be challenging. We investigated middle ear co-infections in adult chinchillas (

Indexed as

Akkaike information criterionCondorcet winnerLotka–Volterramaximum entropy estimationotitis mediapolymicrobial infection

Identifiers

PMID30564392
PMCPMC6281918
OpenAlexW2899720080

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.