Evidence map›Paper›PMID 30564353›Full record

ArticleClinical case reports2018

Complete metabolic response of metastatic castration-resistant neuroendocrine carcinoma of the prostate after treatment with RRx-001 and reintroduced platinum doublets.

Michelle Ojemuyiwa, Karen Zeman, Alexander Spira, Bryan Oronsky, Carolyn Ray, Jane B Trepel, Min-Jung Lee, Ifeyinwa Onyiuke, Christina Brzezniak

Open access · goldAbstract readCase Reports
In one paragraph

Article in Clinical case reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Michelle OjemuyiwaWalter Reed National Military Medical Center Bethesda Maryland.
Karen ZemanWalter Reed National Military Medical Center Bethesda Maryland.
Alexander SpiraVirginia Cancer Specialists (VCS) Fairfax Virginia.
Bryan OronskyEpicentRx San Diego California.ORCID 0000-0002-3940-6329
Carolyn RaySt. Francis Hospital & Medical Center Hartford Connecticut.
Jane B TrepelDevelopmental Therapeutics Branch National Cancer Institute, NIH Bethesda Maryland.
Min-Jung LeeDevelopmental Therapeutics Branch National Cancer Institute, NIH Bethesda Maryland.
Ifeyinwa OnyiukeVA Connecticut Health Care System West Haven Connecticut.
Christina BrzezniakWalter Reed National Military Medical Center Bethesda Maryland.
Walter Reed National Military Medical Center · USNational Cancer Institute · USEpicentre (South Africa) · ZASt. Francis Hospital · USVA Connecticut Healthcare System · USVirginia Cancer Specialists · US

Funding

Signal Transduction Events and the Regulation of Cell GrowthZICSC006743 · NCI · DIVISION OF CLINICAL SCIENCES - NCI · PI TREPEL, JANE B · 2009 to 2023
$13.8M
6 · The paper itself

Abstract

Presented herein is the case of a heavily pretreated patient with high-grade neuroendocrine prostate cancer that achieved a complete metabolic response on platinum-based chemotherapy after treatment with the dual CD-47 and SIRP-α inhibitor, RRx-001, in a Phase II clinical trial.

Indexed as

macrophage repolarizationneuroendocrine cancerplatinum doubletsprimingprostate cancerRRx‐001

Identifiers

PMID30564353
PMCPMC6293266
OpenAlexW2899815668

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.