Evidence map›Paper›PMID 30564300›Full record

ArticleOncotarget2018

Clofarabine/busulfan-based reduced intensity conditioning regimens provides very good survivals in acute myeloid leukemia patients in complete remission at transplant: a retrospective study on behalf of the SFGM-TC.

Amandine Le Bourgeois, Myriam Labopin, Mathieu Leclerc, Régis Peffault de Latour, Jean-Henri Bourhis, Patrice Ceballos, Corentin Orvain, Hélène Labussière Wallet, Karin Bilger, Didier Blaise and 5 more

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 10 institutions in 1 country.

Amandine Le BourgeoisDepartment of Hematology, CHU Hôtel Dieu, Nantes, France.
Myriam LabopinDepartment of Hematology, Hôpital Saint Antoine, Paris, France.
Mathieu LeclercDepartment of Hematology, Hôpital Henri Mondor, Créteil, France.
Régis Peffault de LatourDepartment of Hematology, Hôpital Saint Louis, Université Paris 7, Denis Diderot, Paris, France.
Jean-Henri BourhisDepartment of Hematology, Hôpital Gustave Roussy, Paris, France.
Patrice CeballosDepartment of Hematology, CHU de Montpellier, Montpellier, France.
Corentin OrvainDepartment of Hematology, CHU d'Angers, Angers, France.
Hélène Labussière WalletDepartment of Hematology, Centre Hospitalier Lyon Sud, Lyon, France.
Karin BilgerDepartment of Hematology, CHU Strasbourg, Strasbourg, France.
Didier BlaiseDepartment of Hematology, Centre de Recherche en Cancérologie de Marseille, Institut Paoli Calmettes, Marseille, France.
Marie-Thérese RubioDepartment of Hematology, CHU Nancy, Nancy, France.
Thierry GuillaumeDepartment of Hematology, CHU Hôtel Dieu, Nantes, France.
Mohamad MohtyDepartment of Hematology, Hôpital Saint Antoine, Paris, France.
Patrice ChevallierDepartment of Hematology, CHU Hôtel Dieu, Nantes, France.
Société Francophone de Greffe de Moelle et de Thérapie Cellulaire
Sorbonne Université · FRCentre Hospitalier Régional et Universitaire de Nancy · FRCentre Hospitalier Universitaire de Nantes · FRDélégation Paris 7 · FRCentre de Recherche en Cancérologie de Marseille · FRCentre Hospitalier Universitaire d'Angers · FRCentre Hospitalier Universitaire de Montpellier · FRHôpital Lyon Sud · FRHôtel-Dieu de Paris · FRInstitut Gustave Roussy · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Clofarabine has been proved to have higher anti-leukemic myeloid activity compared to fludarabine, a drug extensively used as part of reduced intensity conditioning (RIC) for allogeneic stem cell transplantation (allo-SCT). Results: Eighty-four patients were included. The majority of patients had acute myeloid leukemia (AML, Conclusions: CloB2A2/A1 RIC regimen provides very good results for AML patients allografted in CR and could be retained as a new RIC platform for these patients. Materials and Methods: This was a retrospective study including all patients who received a clofarabine/busulfan based RIC allo-SCT for myeloid malignancies and reported within the SFGM-TC registry. RIC regimen consisted of clofarabine 30 mg/m

Indexed as

acute myeloid leukemiaallogeneic stem cell transplantationbusulfanclofarabinereduced intensity conditioning regimen

Identifiers

PMID30564300
PMCPMC6290956
OpenAlexW2902583599

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.