Evidence map›Paper›PMID 30564297›Full record

ArticleOncotarget2018

Significance of intranuclear angiotensin-II type 2 receptor in oral squamous cell carcinoma.

Sayako Matsushima-Otsuka, Rina Fujiwara-Tani, Takamitsu Sasaki, Hitoshi Ohmori, Chie Nakashima, Shingo Kishi, Yukiko Nishiguchi, Kiyomu Fujii, Yi Luo, Hiroki Kuniyasu

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Role of Glycated High Mobility Group Box-1 in Gastric Cancer.International journal of molecular sciences · 2021
    Article
  7. Article
  8. Review
  9. Role of Nuclear Claudin-4 in Renal Cell Carcinoma.International journal of molecular sciences · 2020
    Article
  10. Article
  11. Article
  12. Effect of Proton Pump Inhibitors on Colorectal Cancer.International journal of molecular sciences · 2020
    Article
  13. Role ofInternational journal of molecular sciences · 2020
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Sayako Matsushima-OtsukaDepartment of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan.
Rina Fujiwara-TaniDepartment of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan.
Takamitsu SasakiDepartment of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan.
Hitoshi OhmoriDepartment of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan.
Chie NakashimaDepartment of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan.
Shingo KishiDepartment of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan.
Yukiko NishiguchiDepartment of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan.
Kiyomu FujiiDepartment of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan.
Yi LuoJiangsu Province Key Laboratory of Neuroregeneration, Nantong University, Nantong, Jiangsu 226001, China.
Hiroki KuniyasuDepartment of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan.
Nara Medical University · JPNantong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The renin-angiotensin system (RAS) is implicated in the maintenance of blood pressure and in many other biological processes including tumorigenesis and metastasis formation. Angiotensin-II (A-II) type 2 receptor (AGTR2) seems to be involved in different types of cancer; its role, however, is still unclear. Here, we investigated the role of RAS, and specifically that of AGTR2, in oral squamous cell carcinoma (OSCC) progression. AGTR2 has opposite effect on vasodilation and blood pressure compared to AGTR1. In 23 OSCCs, we found that the

Indexed as

AGTR2ARBrenin-angiotensin system

Identifiers

PMID30564297
PMCPMC6290968
OpenAlexW2902674933

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.