Evidence map›Paper›PMID 30564278›Full record

ArticleNutrition & metabolism2018

Palmitate- and C6 ceramide-induced

Adam J Black, Rudolf J Schilder, Scot R Kimball

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrition & metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. More than a messenger: Alternative splicing as a therapeutic target.Biochimica et biophysica acta. Gene regulatory mechanisms
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Adam J Black1Department of Cellular and Molecular Physiology, Penn State College of Medicine, H166, 500 University Drive, Hershey, PA 17033 USA.
Rudolf J Schilder3Department of Entomology and Biology, Penn State University, University Park, PA USA.
Scot R Kimball1Department of Cellular and Molecular Physiology, Penn State College of Medicine, H166, 500 University Drive, Hershey, PA 17033 USA.
Pennsylvania State University · US

Funding

Macronutrient Regulation of Alternative Pre-mRNA SplicingR01DK094141 · NIDDK · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KIMBALL, SCOT R · 2013 to 2016
$1.3M
NIDDK NIH HHS R01 DK094141
6 · The paper itself

Abstract

backgroundIn a previous study, we showed that consumption of diets enriched in saturated fatty acids causes changes in alternative splicing of pre-mRNAs encoding a number of proteins in rat skeletal muscle, including the one encoding skeletal muscle Troponin T (

methodsThe effects of treatment of L6 myotubes with saturated (palmitate), mono- (oleate), or polyunsaturated (linoleate) fatty acids on alternative splicing of pre-mRNA was assessed using

resultsPalmitate treatment caused a two-fold change (

conclusionsOverall, the data show that fatty acid saturation level and ceramides are important factors modulating alternative pre-mRNA splicing through activation of PP2A.

Indexed as

Alternative splicingCeramidesFatty acidsPalmitateProtein phosphatase 2ATnnt3Troponin T

Identifiers

PMID30564278
PMCPMC6296074
OpenAlexW2903767188

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.