Evidence map›Paper›PMID 30564125›Full record

ArticleFrontiers in pharmacology2018

DiDang Tang Inhibits Endoplasmic Reticulum Stress-Mediated Apoptosis Induced by Oxygen Glucose Deprivation and Intracerebral Hemorrhage Through Blockade of the GRP78-IRE1/PERK Pathways.

Qingxia Huang, Tianye Lan, Jing Lu, He Zhang, Dongmei Zhang, Tingting Lou, Peng Xu, Jixiang Ren, Daqing Zhao, Liwei Sun and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 34 citations in OpenAlex.

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  16. The Protective Effect of DiDang Tang Against AlClFrontiers in pharmacology · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Qingxia HuangResearch Center of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.
Tianye LanDepartment of Encephalopathy, Changchun University of Chinese Medicine, Changchun, China.
Jing LuResearch Center of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.
He ZhangResearch Center of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.
Dongmei ZhangScientific Research Office, Changchun University of Chinese Medicine, Changchun, China.
Tingting LouResearch Center of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.
Peng XuDepartment of Encephalopathy, Changchun University of Chinese Medicine, Changchun, China.
Jixiang RenDepartment of Encephalopathy, Changchun University of Chinese Medicine, Changchun, China.
Daqing ZhaoJilin Provincial Key Laboratory of BioMacromolecules of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.
Liwei SunResearch Center of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.
Xiangyan LiJilin Provincial Key Laboratory of BioMacromolecules of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.
Jian WangDepartment of Encephalopathy, Changchun University of Chinese Medicine, Changchun, China.
Changchun University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DiDang Tang (DDT), a Chinese traditional medicine formula, contains 4 Chinese traditional medicine substances, has been widely used to treat intracerebral hemorrhage (ICH) patients. However, the molecular mechanisms of DDT for protecting neurons from oxygen and glucose deprivation (OGD)-induced endoplasmic reticulum (ER) stress and apoptosis after ICH still remains elusive. In this study, high-performance liquid chromatography fingerprint analysis was performed to learn the features of the chemical compositions of DDT. OGD-induced ER stress, Ca

Indexed as

apoptosisDiDang Tangendoplasmic reticulum stress (ER stress)GRP78-IRE1/PERK pathwaysmitochondrial dysfunctionoxygen and glucose deprivation

Identifiers

PMID30564125
PMCPMC6288198
OpenAlexW2902578750

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.