ArticleBritish journal of cancer2019
Kidney stones and the risk of renal cell carcinoma and upper tract urothelial carcinoma: the Netherlands Cohort Study.
Article in British journal of cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.
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Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Associations of Total Protein or Animal Protein Intake and Animal Protein Sources with Risk of Kidney Stones: A Systematic Review and Dose-Response Meta-Analysis.Advances in nutrition (Bethesda, Md.) · 2022Pooled it
- Association between metabolic syndrome components and the risk of developing nephrolithiasis: A systematic review and bayesian meta-analysis.F1000Research · 2021Pooled it
- Dietary and lifestyle factors for primary prevention of nephrolithiasis: a systematic review and meta-analysis.BMC nephrology · 2020Pooled it
- Article
- Upper Tract Urothelial Carcinoma: Molecular Pathogenesis and Current Treatment Strategies-A Narrative Review.Cancers · 2026Review
- Urolithiasis in patients with cancer.Nature reviews. Urology · 2026Review
- Epidemiological Trends and Burden of Adult Kidney Cancer in Saudi Arabia: A 42-Year Retrospective Analysis (1982-2023).Cancer reports (Hoboken, N.J.) · 2026Observational
- Adiposity and cancer: epidemiology, mechanisms and future perspectives.Nature metabolism · 2026Review
- Beyond the stone: nephrolithiasis as a metabolic sentinel in upper tract urothelial carcinoma and papillary renal cell carcinoma: toward a risk-stratified management framework.International urology and nephrology · 2026Review
- Article
- Oxalate induces proliferation and mitochondrial metabolism in select clear cell renal cell carcinoma cell lines.BMC cancer · 2026Article
- Parenchymatous invasive renal pelvis carcinoma in retrograde intrarenal surgery patients: a case report.BMC urology · 2026Article
- Long-term mortality risk in US adults with a history of kidney stones: results from NHANES III with over 30 years of follow-up.International urology and nephrology · 2025Observational
- Kidney Stone History and Survival Outcomes in Upper Tract Urothelial Carcinoma.JAMA network open · 2025Article
- Higher Life's Essential 8 score is associated with lower risk of kidney stones in Chinese adults: a cross-sectional study.BMC public health · 2025Article
- Trend and Cancer-Specific Prevalence of Kidney Stones Among US Cancer Survivors, 2007-2020.Current oncology (Toronto, Ont.) · 2025Article
- Genetic architecture and mechanisms shared between kidney and ureteral stones, cardiovascular diseases, and metabolic syndrome: A comprehensive GWAS analysis.Biochemistry and biophysics reports · 2025Article
- Carcinogenesis Associated with Toxin Nephropathy: Proposed Mediation by Phosphate Toxicity.Cells · 2025Review
- Increased risk of upper tract urothelial carcinoma in patients with kidney stones: a large-scale analysis of the UK biobank.Urolithiasis · 2025Article
- Association between kidney stones and urological cancers: results from the NHANES 2007-2020 and Mendelian randomization study.Discover oncology · 2025Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe examined the association between kidney stones and renal cell carcinoma (RCC) and upper tract urothelial carcinoma (UTUC) risk in the Netherlands Cohort Study on diet and cancer.
methodsIn total, 120,852 participants aged 55-69 completed a self-administered questionnaire on diet, medical conditions and other risk factors for cancer at baseline (1986). After 20.3 years of cancer follow-up 4352 subcohort members, 544 RCC cases and 140 UTUC cases were eligible for case-cohort analysis. Hazard ratios (HR) and 95% confidence intervals (CIs) were estimated by multivariable-adjusted proportional hazards models.
resultsKidney stones were associated with an increased RCC risk (HR: 1.39, 95% CI 1.05-1.84), vs. no kidney stones. Kidney stones were associated with an increased risk of papillary RCC (HR: 3.08, 95% CI 1.55-6.11), but not clear-cell RCC (HR: 1.14, 95% CI 0.79-1.65). UTUC risk was increased for participants with kidney stones (HR: 1.66, 95% CI 1.03-2.68). No heterogeneity of associations was found for UTUC in the ureter and renal pelvis. An early kidney stone diagnosis (≤40 years) was associated with an increased RCC and UTUC risk, compared to later diagnosis.
conclusionKidney stones were associated with increased papillary RCC risk, but not clear-cell RCC risk. No heterogeneity was found for UTUC subtypes.
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