ArticleTranslational psychiatry2018
Sex difference in association of symptoms and white matter deficits in first-episode and drug-naive schizophrenia.
Article in Translational psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Sex and gender differences in symptoms of early psychosis: a systematic review and meta-analysis.Archives of women's mental health · 2022Pooled it
- Brain structural correlates of familial risk for mental illness: a meta-analysis of voxel-based morphometry studies in relatives of patients with psychotic or mood disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Pooled it
- Prenatal Exposure to Tobacco Smoke and Vaping Aerosols: Mechanisms Disrupting White-Matter Formation.Toxics · 2025Review
- Repurposing medications to prevent psychosis.Npj mental health research · 2025Review
- Evenamide reverses schizophrenia-related dysfunction in a neurodevelopmental animal model.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Linking Psychotic-Like Experiences and Brain White Matter Microstructure in Young Women.Brain and behavior · 2025Article
- Effects on Multimodal Connectivity Patterns in Female Schizophrenia During 8 Weeks of Antipsychotic Treatment.Schizophrenia bulletin · 2025Article
- Characterizing multivariate regional hubs for schizophrenia classification, sex differences, and brain age estimation using explainable AI.medRxiv : the preprint server for health sciences · 2025Article
- Genetic association between gene expression profiles in oligodendrocyte precursor cells and psychiatric disorders.Frontiers in psychiatry · 2025Article
- Correlation study of BDNF/TrkB/CREB, violence, and cognitive function in first-episode drug-naive schizophrenia patients.Frontiers in psychiatry · 2025Article
- Association of P50 with social function, but not with cognition in patients with first-episode schizophrenia.European archives of psychiatry and clinical neuroscience · 2024Article
- Gender differences in cognitive improvements after two months of atypical antipsychotic treatment in first episode schizophrenia.Frontiers in psychiatry · 2024Article
- Traveling Subject-Informed Harmonization Increases Reliability of Brain Diffusion Tensor and Neurite Mapping.Aging and disease · 2023Article
- Structural impairment in superficial and deep white matter in schizophrenia.Acta neuropsychiatrica · 2023Article
- Sex differences in the clinical presentation of early psychosis in a primary care setting.Archives of women's mental health · 2023Article
- Gamma-Aminobutyric Acid Type A Receptor Variants are Associated with Autism Spectrum Disorders.Journal of molecular neuroscience : MN · 2023Article
- NKCC1 to KCC2 mRNA Ratio in Schizophrenia and Its Psychopathology: a Case-Control Study.Journal of molecular neuroscience : MN · 2022Article
- Bridging structural MRI with cognitive function for individual level classification of early psychosisFrontiers in psychiatry · 2022Article
- Sex Differences in Obesity and Cognitive Function in Chinese Elderly Patients With Chronic Schizophrenia.Frontiers in endocrinology · 2022Article
- White Matter Integrity of the Corpus Callosum and Psychopathological Dimensions in Deficit and Non-Deficit Schizophrenia Patients.Journal of clinical medicine · 2021Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accumulating evidence shows that disruption of white matter (WM) may be involved in the pathophysiology of schizophrenia, even at the onset of psychosis. However, very few studies have explored sex difference in its association with psychopathology in schizophrenia. This study aims to compare sex differences in clinical features and WM abnormalities in first-episode and drug-naive (FEDN) schizophrenia among Han Chinese inpatients. The WM fractional anisotropy (FA) values of the whole-brain were determined using voxel-based diffusion tensor imaging (DTI) in 39 (16 males and 23 females) FEDN patients with schizophrenia and 30 healthy controls (13 males and 17 females) matched for gender, age, and education. Patient psychopathology was assessed using the Positive and Negative Syndrome Scale (PANSS).Our results showed that compared with the controls, the patients showed widespread areas of lower FA, including corpus callosum, brainstem, internal capsule, cingulate, and cerebellum (all adjusted p < 0.01). Further, male patients showed lower FA values in left cingulate (F = 4.92, p = 0.033), but higher scores on the PANSS total, positive, and general psychopathology subscale scores (all p < 0.01) than female patients. Multivariate regression analysis showed that for male patients, FA values in right corpus callosum were positively associated with the PANSS total (beta = 0.785, t = 3.76, p = 0.002) and the negative symptom scores (beta = 0.494, t = 2.20, p = 0.044), while for female patients, FA values in left cingulate were negatively associated with the PANSS positive symptom score (beta = -0.717, t = -2.25, p = 0.041). Our findings indicate sex difference in white matter disconnectivity and its association with psychopathological symptoms in an early course of schizophrenia onset.
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