Evidence map›Paper›PMID 30563928›Full record

ArticleBioscience reports2019

MicroRNA-625 inhibits cell invasion and epithelial-mesenchymal transition by targeting SOX4 in laryngeal squamous cell carcinoma.

Yuan Li, Chenjuan Tao, Lili Dai, Caixia Cui, Chaohui Chen, Honglin Wu, Qingyu Wei, Xuehua Zhou

RetractedOpen access · goldAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioscience reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Crucial Roles of miR-625 in Human Cancer.Frontiers in medicine · 2022
    Review
  6. Article
  7. Overexpression of Laminin 5Journal of oncology · 2022
    Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yuan LiDepartment of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China.
Chenjuan TaoDepartment of Neurology, Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China.
Lili DaiDepartment of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China.
Caixia CuiDepartment of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China.
Chaohui ChenDepartment of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China.
Honglin WuDepartment of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China.
Qingyu WeiDepartment of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China.
Xuehua ZhouDepartment of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China xuehuazhou22@163.com.
Affiliated Hospital of Hangzhou Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionLaryngeal squamous cell carcinoma (LSCC) is a highly aggressive malignant cancer, but the molecular mechanisms underlying its development and progression remain largely elusive. The purpose of the present study is to investigate the expression profile and functional role of microRNA-625 (miR-625) in LSCC. MATERIALS AND

methodsLSCC tissues and adjacent normal tissues were collected from 86 LSCC patients. The expression levels of miR-625 and SOX4 mRNA in tissues and cells were detected by RT-qPCR analysis. The expression levels of SOX4 and EMT-related proteins were detected by western blot analysis.

resultsThe results demonstrated that miR-625 is significantly down-regulated in clinical LSCC tissues, and its low expression may be closely associated with unfavorable clinicopathological characteristics of LSCC patients. Overexpression of miR-625 significantly suppressed the proliferation, migration, invasion, and EMT of LSCC cells. Furthermore, SOX4 was validated as a direct target of miR-625 in LSCC cells, and rescue experiments suggested that restoration of SOX4 blocked the tumor suppressive role of miR-625 in LSCC cells.

conclusionsTaken together, these findings highlighted a critical role of miR-625 in the pathogenesis of LSCC, and restoration of miR-625 could be considered as a potential therapeutic strategy against this fatal disease.

Indexed as

AgedCarcinoma, Squamous CellCell Line, TumorDown-RegulationEpithelial-Mesenchymal TransitionFemaleGene Expression Regulation, NeoplasticHumansLaryngeal NeoplasmsMaleMicroRNAsMiddle AgedSOXC Transcription FactorsMicroRNAsMIRN625 microRNA, humanSOX4 protein, humanSOXC Transcription Factorsepithelial-mesenchymal transitionlaryngeal squamous cell carcinomamicroRNA-625SOX4

Identifiers

PMID30563928
PMCPMC6340973
OpenAlexW2904554292

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.