Evidence map›Paper›PMID 30563900›Full record

ArticlemBio2018

Exoribonuclease-Resistant RNAs Exist within both Coding and Noncoding Subgenomic RNAs.

Anna-Lena Steckelberg, Quentin Vicens, Jeffrey S Kieft

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 59 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. A Genetic Circuit Design for Targeted Viral RNA Degradation.Bioengineering (Basel, Switzerland) · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Anna-Lena Steckelberg *Department of Biochemistry and Molecular Genetics and RNA BioScience Initiative, University of Colorado Denver School of Medicine, Aurora, Colorado, USA.
Quentin Vicens *Department of Biochemistry and Molecular Genetics and RNA BioScience Initiative, University of Colorado Denver School of Medicine, Aurora, Colorado, USA quentin.vicens@ucdenver.edu jeffrey.kieft@ucdenver.edu.
Jeffrey S KieftDepartment of Biochemistry and Molecular Genetics and RNA BioScience Initiative, University of Colorado Denver School of Medicine, Aurora, Colorado, USA quentin.vicens@ucdenver.edu jeffrey.kieft@ucdenver.edu.
University of Colorado Denver · US

Funding

Structure, function, and dynamics of viral RNAs and RNA-containing complexesR35GM118070 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI Jeffrey S Kieft · 2016 to 2026
$10.6M
Mechanisms of viral RNA maturation by co-opting cellular exonucleasesR01AI133348 · NIAID · UNIVERSITY OF COLORADO DENVER · PI KIEFT, JEFFREY S · 2017 to 2025
$4.5M
NIAID NIH HHS R01 AI133348NIGMS NIH HHS R35 GM118070
6 · The paper itself

Abstract

Many viruses produce protein-coding and noncoding subgenomic RNAs (sgRNAs) that are critical for infection. A recently discovered pathway for viral sgRNA production uses exoribonuclease-resistant RNAs (xrRNAs), discrete folded RNA elements that block the processive exoribonucleolytic degradation of RNA. xrRNAs are widespread in animal-infecting flaviviruses but had been found only in three members of the plant virus genus

Indexed as

DNA, IntergenicExoribonucleasesGenome, ViralPlant VirusesRNA, UntranslatedRNA, ViralViral ProteinsDNA, IntergenicExoribonucleasesRNA, UntranslatedRNA, ViralViral Proteinsexoribonuclease resistanceInfernalplant virusesRNA structureviral RNA

Identifiers

PMID30563900
PMCPMC6299227
OpenAlexW2905299404

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.