Evidence map›Paper›PMID 30563896›Full record

ArticlemBio2018

Transcriptional Profiling of Patient Isolates Identifies a Novel TOR/Starvation Regulatory Pathway in Cryptococcal Virulence.

Yoon-Dong Park, Joseph N Jarvis, Guowu Hu, Sarah E Davis, Jin Qiu, Nannan Zhang, Christopher Hollingsworth, Angela Loyse, Paul J Gardina, Tibor Valyi-Nagy and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Low Glucose Mediated Fluconazole Tolerance inJournal of fungi (Basel, Switzerland) · 2021
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Yoon-Dong ParkLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA yoon-dong.park@nih.gov williamsonpr@mail.nih.gov.
Joseph N JarvisBotswana-UPenn Partnership, Gaborone, Botswana.
Guowu HuLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Sarah E DavisLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Jin QiuLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Nannan ZhangLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Christopher HollingsworthLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Angela LoyseGlobal Health Group, Department of Infection and Immunity, St. George's University of London, London, United Kingdom.
Paul J GardinaGenomic Technologies Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Tibor Valyi-NagyDepartment of Pathology, University of Illinois at Chicago, Chicago, Illinois, USA.
Timothy G MyersGenomic Technologies Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Thomas S HarrisonInstitute of Infection and Immunity, St. George's University of London, London, United Kingdom.
Tihana BicanicInstitute of Infection and Immunity, St. George's University of London, London, United Kingdom.
Peter R WilliamsonLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA yoon-dong.park@nih.gov williamsonpr@mail.nih.gov.
National Institute of Allergy and Infectious Diseases · USNational Institutes of Health · USSt George's, University of London · GBUniversity of Illinois Chicago · USUniversity of Pennsylvania · US

Funding

Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI DAVID S METZGER · 1999 to 2026
$78.6M
Molecular Pathobiology of Cryptococcus neoformansZIAAI001123 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI WILLIAMSON, PETER · 2010 to 2025
$10.4M
Translational Research: Host-Pathogen Interactions in Patient Fungal DiseasesZIAAI001124 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI WILLIAMSON, PETER · 2010 to 2025
$8.8M
NIAID NIH HHS P30 AI045008Wellcome TrustWellcome Trust WT081794Wellcome Trust WT 089966
6 · The paper itself

Abstract

Human infection with

Indexed as

AdultAnimalsCryptococcus neoformansDisease Models, AnimalFemaleGene Expression ProfilingGenes, RegulatorHIV InfectionsHost-Pathogen InteractionsHumansMaleMembrane Transport ProteinsMeningitis, CryptococcalMetabolic Networks and PathwaysMiceMice, Inbred CBAMembrane Transport ProteinsTOR Serine-Threonine KinasesVirulence FactorsCAC2CAF-1Cryptococcus neoformansSTL1TOR pathwayVAD1

Identifiers

PMID30563896
PMCPMC6299223
OpenAlexW2951494170

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.