ArticleCancer research2019
The WNT10B Network Is Associated with Survival and Metastases in Chemoresistant Triple-Negative Breast Cancer.
Open access · bronzeAbstract read
In one paragraph
Article in Cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Unraveling Biomarker Signatures in Triple-Negative Breast Cancer: A Systematic Review for Targeted Approaches.International journal of molecular sciences · 2024Pooled it
- Article
- Discovery of Potent and Brain-Penetrable Tubulin Inhibitors that Effectively Suppress Breast Cancer Brain Metastasis.Molecular cancer therapeutics · 2026Article
- Wnt ligands in breast cancer metastasis: unraveling their dual roles and therapeutic potential.Molecular biology reports · 2026Review
- Mechanistic Insights into Tumorigenesis from Serum Proteins.medRxiv : the preprint server for health sciences · 2025Article
- Regulation of the β‑catenin/LEF‑1 pathway by the siRNA knockdown of RUVBL1 expression inhibits breast cancer cell proliferation, migration and invasion.Oncology reports · 2025Article
- Single-Cell RNA Sequencing Reveals LEF1-Driven Wnt Pathway Activation as a Shared Oncogenic Program in Hepatoblastoma and Medulloblastoma.Current oncology (Toronto, Ont.) · 2025Article
- Unleashing Wnts: Wnt Ligands Fuel Cancer Spread.Journal of cancer biology · 2025Article
- The roles of patient-derived xenograft models and artificial intelligence toward precision medicine.MedComm · 2024Review
- Biological activity of a stable 6-aryl-2-benzoyl-pyridine colchicine-binding site inhibitor, 60c, in metastatic, triple-negative breast cancer.Cancer letters · 2024Article
- The emerging role and mechanism of HMGA2 in breast cancer.Journal of cancer research and clinical oncology · 2024Review
- The progressive trend of modeling and drug screening systems of breast cancer bone metastasis.Journal of biological engineering · 2024Review
- HMGA2 promotes cancer metastasis by regulating epithelial-mesenchymal transition.Frontiers in oncology · 2024Review
- Current insights into the oncogenic roles of lncRNA LINC00355.Cancer innovation · 2023Review
- Lymphoma in Border Collies: Genome-Wide Association and Pedigree Analysis.Veterinary sciences · 2023Article
- Chemotherapy-induced metastasis: molecular mechanisms and clinical therapies.Acta pharmacologica Sinica · 2023Review
- Ezh2 promotes mammary tumor initiation through epigenetic regulation of the Wnt and mTORC1 signaling pathways.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Review
- Adaptive and non-adaptive gene expression responses in prostate cancer during androgen deprivation.PloS one · 2023Article
- The role of WNT10B in physiology and disease: A 10-year update.Frontiers in cell and developmental biology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 8 institutions in 2 countries.
Ikbale El AyachiDepartment of Medicine, College of Medicine at UTHSC, UTHSC Center for Cancer Research, Memphis, Tennessee.
Iram FatimaDepartment of Medicine, College of Medicine at UTHSC, UTHSC Center for Cancer Research, Memphis, Tennessee.
Peter WendDepartment of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Jonsson Comprehensive Cancer Center, Los Angeles, California.
Jackelyn A Alva-OrnelasDepartment of Population Science, City of Hope Comprehensive Cancer Center and Beckman Institute, Duarte, California.
Stephanie RunkeDepartment of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Jonsson Comprehensive Cancer Center, Los Angeles, California.
William L KuenzingerDepartment of Medicine, College of Medicine at UTHSC, UTHSC Center for Cancer Research, Memphis, Tennessee.
Julio SilvaDepartment of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Jonsson Comprehensive Cancer Center, Los Angeles, California.
Wendy SilvaDepartment of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Jonsson Comprehensive Cancer Center, Los Angeles, California.
Joseph K GrayDepartment of Medicine, College of Medicine at UTHSC, UTHSC Center for Cancer Research, Memphis, Tennessee.
Stephan LehrBaxter Innovations GmbH, Vienna, Austria.
Hilaire C BarchDepartment of Pathology and Laboratory Medicine, College of Medicine at UTHSC, UTHSC Center for Cancer Research, Memphis, Tennessee.
Raisa I KrutilinaDepartment of Pathology and Laboratory Medicine, College of Medicine at UTHSC, UTHSC Center for Cancer Research, Memphis, Tennessee.
Andrew C WhiteDepartment of Biomedical Sciences, Cornell University, Ithaca, New York.
Robert CardiffDepartment of Medical Pathology, School of Medicine, University of California, Davis, California.ORCID 0000-0003-3088-8816
Lisa D YeeDepartment of Surgery, City of Hope Comprehensive Cancer Center, Duarte, California.
Lily YangDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia.
Ruth M O'ReganDivision of Hematology and Oncology, Departments of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
William E LowryMolecular, Cell and Developmental Biology, University of California, Los Angeles, California.ORCID 0000-0003-2932-2276
Tiffany N SeagrovesDepartment of Pathology and Laboratory Medicine, College of Medicine at UTHSC, UTHSC Center for Cancer Research, Memphis, Tennessee.ORCID 0000-0002-6937-943X
Victoria SeewaldtDepartment of Population Science, City of Hope Comprehensive Cancer Center and Beckman Institute, Duarte, California.
Susan A KrumDepartment of Orthopaedic Surgery and Biomedical Engineering, UTHSC Center for Cancer Research, UTHSC, Memphis, Tennessee.ORCID 0000-0002-6414-6397
Gustavo A Miranda-CarboniDepartment of Medicine, College of Medicine at UTHSC, UTHSC Center for Cancer Research, Memphis, Tennessee. gmirand1@uthsc.edu.
University of Tennessee Health Science Center · USUniversity of California, Los Angeles · USCity of Hope · USBaxter (Austria) · ATCornell University · USEmory University · USUniversity of California Davis Medical Center · USUniversity of Wisconsin–Madison · US
Funding
Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI STANLEY R. HAMILTON · 1985 to 2026
$86.3MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MUCLA MSD ProgramR25GM055052 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BARBER, PAUL HENRY, HASSON, TAMA W. · 1996 to 2021
$9.2MDiversity Supplement to Combined Breast MRI/Biomarker Strategies to Identify Aggressive BiologyU01CA189283 · NCI · DUKE UNIVERSITY · PI CLINTON, STEVEN K, MIRANDA-CARBONI, GUSTAVO ADOLFO · 2015 to 2020
$4.0MTension-Stat3-miR-mediated metastasisR01CA192914 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SEEWALDT, VICTORIA L., WEAVER, VALERIE MARIE · 2015 to 2019
$2.9MMetabolic Control of Hair Follicle Stem Cell Homeostasis and TumorigenesisR01AR070245 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHRISTOFK, HEATHER, LOWRY, WILLIAM E · 2018 to 2022
$2.1MTargeted Chemoprevention of Breast Cancer: From the Bench to Clinical TestingR01CA158668 · NCI · DUKE UNIVERSITY · PI SEEWALDT, VICTORIA L. · 2012 to 2016
$1.7MTargeted Therapy of Triple Negative Breast Cancer Using Theranostic NanoparticlesR01CA154129 · NCI · EMORY UNIVERSITY · PI YANG, LILY · 2011 to 2015
$1.7MThe Role of HIF-1alpha in Breast Cancer Stem Cell ActivityR01CA138488 · NCI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SEAGROVES, TIFFANY NICOLE · 2010 to 2014
$1.5MWnt10b's Functional Role on Mammary Stem CellsK22CA137168 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIRANDA-CARBONI, GUSTAVO ADOLFO · 2009 to 2011
$564kThe role of WNT10B and HMGA2 in Lung Metastasis in Triple Negative Breast CancerR21CA179735 · NCI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI MIRANDA, SUSAN A, MIRANDA-CARBONI, GUSTAVO ADOLFO · 2013 to 2014
$359kNCATS NIH HHS UL1 TR000124NCI NIH HHS K22 CA137168NCI NIH HHS P30 CA033572NCI NIH HHS R01 CA138488NCI NIH HHS R01 CA154129NCI NIH HHS R01 CA158668NCI NIH HHS R01 CA192914NCI NIH HHS R21 CA179735NCI NIH HHS U01 CA189283NIAMS NIH HHS R01 AR070245NIGMS NIH HHS R25 GM055052
Abstract
Triple-negative breast cancer (TNBC) commonly develops resistance to chemotherapy, yet markers predictive of chemoresistance in this disease are lacking. Here, we define WNT10B-dependent biomarkers for β-CATENIN/HMGA2/EZH2 signaling predictive of reduced relapse-free survival. Concordant expression of HMGA2 and EZH2 proteins is observed in
Indexed as
AcetylationAllelesAnimalsAntineoplastic Combined Chemotherapy Protocolsbeta CateninBiomarkers, TumorBridged Bicyclo Compounds, HeterocyclicCell Line, TumorDoxorubicinDrug Resistance, NeoplasmDrug SynergismEnhancer of Zeste Homolog 2 ProteinFemaleHMGA2 ProteinHumansLymphoid Enhancer-Binding Factor 1beta CateninBiomarkers, TumorBridged Bicyclo Compounds, HeterocyclicCTNNB1 protein, humanDoxorubicinEnhancer of Zeste Homolog 2 ProteinEZH2 protein, humanHMGA2 ProteinHMGA2 protein, humanICG 001LEF1 protein, humanLymphoid Enhancer-Binding Factor 1Proto-Oncogene ProteinsPyrimidinonesTCF4 protein, humanTranscription Factor 4WNT10B protein, humanWnt Proteins
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.