ArticleScience signaling2018
ORAI1, STIM1/2, and RYR1 shape subsecond Ca
Open access · greenAbstract read
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Article in Science signaling, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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0cells of the map it votes in
54citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
54 citing papers in PubMed, 74 citations in OpenAlex.
- Ryanodine Receptor 1 Is Dispensable for CD4European journal of immunology · 2026Article
- Guardians of T-Cell CaCells · 2026Review
- Two-pore channel-2 controls calmodulin-dependent STIM1 inactivation.Nature communications · 2026Article
- The scramblase anoctamin 9 controls the immune response in lymphocytes.Cellular and molecular life sciences : CMLS · 2026Article
- Mechanism of action of two potent LRRC8/VRAC channel inhibitors.Research square · 2026Article
- Identification of characteristic hub genes in the immune-active phase of chronic hepatitis B.Frontiers in immunology · 2026Article
- Single-Molecule and Super-Resolution Techniques for Investigating Protein Organizations and Biological Functions of Immune Cells.Advances in experimental medicine and biology · 2026Review
- Identification of non-cardiomyocytes marker genes in patients with diabetes and cardiomyopathy through single-cell analysis.PloS one · 2026Article
- Article
- Thrombospondin-1-CD47 signaling contributes to the development of T cell exhaustion in cancer.Nature immunology · 2025Article
- Inter-Organellar CaCells · 2025Review
- Measuring NAADP-Evoked CaMethods in molecular biology (Clifton, N.J.) · 2025Article
- Imaging Protocol for Super-Resolution Microscopy in Fixed T Cells.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Channel plan: control of adaptive immune responses by pannexins.Trends in immunology · 2024Review
- MASTER-NAADP: a membrane permeable precursor of the CaNature communications · 2024Article
- Time-resolved role of P2X4 and P2X7 during CD8Frontiers in immunology · 2024Article
- Tissue- and temporal-specific roles of extracellular ATP on T cell metabolism and function.Immunometabolism (Cobham, Surrey) · 2023Review
- Cortisol Rapidly Facilitates Glucocorticoid Receptor Translocation to the Plasma Membrane in Primary Trout Hepatocytes.Biology · 2023Article
- Super resolution microscopy analysis reveals increased Orai1 activity in asthma and cystic fibrosis lungs.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2023Article
- DARTS: an open-source Python pipeline for CaFrontiers in immunology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 4 institutions in 2 countries.
Björn-Philipp DiercksThe Calcium Signaling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0002-6635-1706
René WernerDepartment of Computational Neuroscience, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0002-2296-3305
Paula WeidemüllerThe Calcium Signaling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.
Frederik CzarniakThe Calcium Signaling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0003-2427-4607
Lola HernandezThe Calcium Signaling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.
Cari LehmannThe Calcium Signaling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0003-3476-9005
Annette RoscheThe Calcium Signaling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.
Aileen KrügerThe Calcium Signaling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.
Ulrike KaufmannDepartment of Pathology, New York University School of Medicine, New York, NY 10016, USA.
Martin VaethDepartment of Pathology, New York University School of Medicine, New York, NY 10016, USA.ORCID 0000-0001-8974-7052
Antonio V FaillaMicroscopy Core Facility, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.
Bernd ZobiakMicroscopy Core Facility, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.
Farid I KandilDepartment of Computational Neuroscience, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0003-3071-7902
Daniel ScheteligDepartment of Computational Neuroscience, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0001-8117-0287
Alexandra RuthenbeckOrganic Chemistry, University of Hamburg, 20146 Hamburg, Germany.ORCID 0000-0001-7766-1868
Chris MeierOrganic Chemistry, University of Hamburg, 20146 Hamburg, Germany.
Dmitri LodyginInstitute of Neuroimmunology, University of Göttingen, 37075 Göttingen, Germany.
Alexander FlügelInstitute of Neuroimmunology, University of Göttingen, 37075 Göttingen, Germany.
Dejian RenDepartment of Biology, University of Pennsylvania, Philadelphia, PA 19104-6313, USA.
Insa M A WolfThe Calcium Signaling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.
Stefan FeskeDepartment of Pathology, New York University School of Medicine, New York, NY 10016, USA.
Andreas H GuseThe Calcium Signaling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany. guse@uke.de.ORCID 0000-0002-3972-401X
Universität Hamburg · DENew York University · USEuropean Neuroscience Institute Göttingen · DEUniversity of Pennsylvania · US
Funding
CRAC Channel Deficiency in Immunity to InfectionR01AI097302 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FESKE, STEFAN · 2012 to 2022
$5.6MSodium Leak Channels and Regulation by NeurotransmittersR01NS055293 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI REN, DEJIAN · 2008 to 2017
$3.6MRegulation of encephalitogenic T cells by CRAC channelsR01AI137004 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FESKE, STEFAN · 2018 to 2022
$2.4MRegulation of Neuronal Excitability by Extracellular CalciumR01NS074257 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI REN, DEJIAN · 2011 to 2015
$1.7MModulation of ORAI2 and ORAI3 Calcium ChannelsR21AI107448 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FESKE, STEFAN · 2016 to 2017
$466kNIAID NIH HHS R01 AI097302NIAID NIH HHS R01 AI137004NIAID NIH HHS R21 AI107448NINDS NIH HHS R01 NS055293NINDS NIH HHS R01 NS074257
Abstract
The earliest intracellular signals that occur after T cell activation are local, subsecond Ca
Indexed as
Lymphocyte ActivationAnimalsCalciumCalcium SignalingCell MembraneCells, CulturedFemaleFluorescence Resonance Energy TransferMaleMembrane MicrodomainsMiceMice, Inbred C57BLMice, KnockoutORAI1 ProteinRyanodine Receptor Calcium Release ChannelStromal Interaction Molecule 1CalciumORAI1 ProteinOrai1 protein, mouseryanodine receptor 1, mouseRyanodine Receptor Calcium Release ChannelStim1 protein, mouseStim2 protein, mouseStromal Interaction Molecule 1Stromal Interaction Molecule 2
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.