ArticleProceedings of the National Academy of Sciences of the United States of America2019
Dorsal striatal dopamine D1 receptor availability predicts an instrumental bias in action learning.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 49 citations in OpenAlex.
- Activation of D1 receptors affects human reactivity and flexibility to valued cues.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Impaired midfrontal‑motor theta phase synchronization characterizes maladaptive motivational behavior in people with obsessive‑compulsive disorder.PLoS biology · 2026Article
- Article
- Ultrasound neuromodulation reveals distinct roles of the dorsal anterior cingulate cortex and anterior insula in learning.PLoS biology · 2026Article
- The Role of Pavlovian Bias in Smoking Cessation Success and Neurocognitive Alterations During Nicotine Withdrawal.bioRxiv : the preprint server for biology · 2025Article
- Emotional cues reduce Pavlovian interference in feedback-based go and nogo learning.Psychological research · 2024Article
- Dopamine D1-Receptor Organization Contributes to Functional Brain Architecture.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Prefrontal signals precede striatal signals for biased credit assignment in motivational learning biases.Nature communications · 2024Article
- The neurocognitive role of working memory load when Pavlovian motivational control affects instrumental learning.PLoS computational biology · 2023Article
- Interindividual differences in Pavlovian influence on learning are consistent.Royal Society open science · 2023Article
- The passive avoidance task ameliorate the toxic effects of bisphenol A on dopamine D1 receptor density in hippocampus, amygdala, and cerebellum of male rats.Brain and behavior · 2023Article
- Interpreting the role of the striatum during multiple phases of motor learning.The FEBS journal · 2022Review
- Is Adolescence a Sensitive Period for the Development of Incentive-Reward Motivation?Current topics in behavioral neurosciences · 2022Review
- Motivational learning biases are differentially modulated by genetic determinants of striatal and prefrontal dopamine function.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Dopamine D1 and D2 receptors are distinctly associated with rest-activity rhythms and drug reward.The Journal of clinical investigation · 2021Article
- In vivo imaging of dopamine D1 receptor and activated microglia in attention-deficit/hyperactivity disorder: a positron emission tomography study.Molecular psychiatry · 2021Article
- Article
- Role of dopamine and gray matter density in aging effects and individual differences of functional connectomes.Brain structure & function · 2021Article
- Overcoming Pavlovian bias in semantic space.Scientific reports · 2021Article
- Neural signatures of arbitration between Pavlovian and instrumental action selection.PLoS computational biology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Learning to act to obtain reward and inhibit to avoid punishment is easier compared with learning the opposite contingencies. This coupling of action and valence is often thought of as a Pavlovian bias, although recent research has shown it may also emerge through instrumental mechanisms. We measured this learning bias with a rewarded go/no-go task in 60 adults of different ages. Using computational modeling, we characterized the bias as being instrumental. To assess the role of endogenous dopamine (DA) in the expression of this bias, we quantified DA D1 receptor availability using positron emission tomography (PET) with the radioligand [
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.