ArticleG3 (Bethesda, Md.)2019
A Strategy To Exploit Surrogate Sire Technology in Livestock Breeding Programs.
Article in G3 (Bethesda, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Considerations for recipient male selection in a livestock Surrogate Sire breeding strategy.The Journal of reproduction and development · 2026Review
- Male germ cell technologies in large animals.The Journal of reproduction and development · 2026Review
- Current and future uses of genetic improvement technologies in livestock breeding programs.Animal frontiers : the review magazine of animal agriculture · 2025Article
- Germline ablation achieved via CRISPR/Cas9 targeting ofFrontiers in genome editing · 2023Article
- Modeling suggests gene editing combined with vaccination could eliminate a persistent disease in livestock.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Culture of Kenyan Goat (Frontiers in veterinary science · 2022Article
- Comparative Efficiency for in vitro Transfection of Goat Undifferentiated Spermatogonia Using Lipofectamine Reagents and Electroporation.Stem cells and cloning : advances and applications · 2022Article
- 25th ANNIVERSARY OF CLONING BY SOMATIC-CELL NUCLEAR TRANSFER: Nuclear transfer and the development of genetically modified/gene edited livestock.Reproduction (Cambridge, England) · 2021Review
- Robust modeling of additive and nonadditive variation with intuitive inclusion of expert knowledge.Genetics · 2021Article
- Spermatogonial Stem Cell Transplantation in Large Animals.Animals : an open access journal from MDPI · 2021Review
- Core-dependent changes in genomic predictions using the Algorithm for Proven and Young in single-step genomic best linear unbiased prediction.Journal of animal science · 2020Article
- Donor-derived spermatogenesis following stem cell transplantation in sterileProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Surrogate broodstock to enhance biotechnology research and applications in aquaculture.Biotechnology advancesReview
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Authors and funding
10 authors.
Funding
Abstract
In this work, we performed simulations to develop and test a strategy for exploiting surrogate sire technology in animal breeding programs. Surrogate sire technology allows the creation of males that lack their own germline cells, but have transplanted spermatogonial stem cells from donor males. With this technology, a single elite male donor could give rise to huge numbers of progeny, potentially as much as all the production animals in a particular time period. One hundred replicates of various scenarios were performed. Scenarios followed a common overall structure but differed in the strategy used to identify elite donors and how these donors were used in the product development part. The results of this study showed that using surrogate sire technology would significantly increase the genetic merit of commercial sires, by as much as 6.5 to 9.2 years' worth of genetic gain compared to a conventional breeding program. The simulations suggested that a strategy involving three stages (an initial genomic test followed by two subsequent progeny tests) was the most effective of all the strategies tested. The use of one or a handful of elite donors to generate the production animals would be very different to current practice. While the results demonstrate the great potential of surrogate sire technology there are considerable risks but also other opportunities. Practical implementation of surrogate sire technology would need to account for these.
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