Evidence map›Paper›PMID 30563576›Full record

ArticleRespiratory research2018

Centrilobular emphysema and coronary artery calcification: mediation analysis in the SPIROMICS cohort.

Surya P Bhatt, Hrudaya P Nath, Young-Il Kim, Rekha Ramachandran, Jubal R Watts, Nina L J Terry, Sushil Sonavane, Swati P Deshmane, Prescott G Woodruff, Elizabeth C Oelsner and 8 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01969344 (Subpopulations and Intermediate Outcome Measures in COPD Study), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01969344 active not recruitingnot on this map

Subpopulations and Intermediate Outcome Measures in COPD Study

TypeobservationalSponsorUniversity of North Carolina, Chapel HillRan2010 to 2031Enrolled2,981ConditionsCOPD, Chronic Obstructive Pulmonary Disease, Chronic Bronchitis, Emphysema
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Methods to assess atherosclerotic cardiovascular risk in chronic respiratory diseases: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2025
    Pooled it
  2. Review
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  7. Plasma Levels of CXCL9 and MCP-3 are Increased in Asthma-COPD Overlap (ACO) Patients.International journal of chronic obstructive pulmonary disease · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 1 country.

Surya P BhattDivision of Pulmonary, Allergy and Critical Care Medicine and Lung Health Center, University of Alabama at Birmingham, THT 422, 1720, 2nd Avenue South, Birmingham, AL, 35294, USA. sbhatt@uabmc.edu.ORCID http://orcid.org/0000-0002-8418-4497
Hrudaya P NathUAB Lung Imaging Core, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Young-Il KimDivision of Pulmonary, Allergy and Critical Care Medicine and Lung Health Center, University of Alabama at Birmingham, THT 422, 1720, 2nd Avenue South, Birmingham, AL, 35294, USA.
Rekha RamachandranDepartment of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Jubal R WattsDepartment of Radiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Nina L J TerryDepartment of Radiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Sushil SonavaneDepartment of Radiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Swati P DeshmaneDepartment of Radiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Prescott G WoodruffDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, University California San Francisco, San Francisco, CA, 94143, USA.
Elizabeth C OelsnerDivision of Pulmonary, Allergy and Critical Care Medicine, Columbia University Medical Center, New York, NY, 10032, USA.
Sandeep BodduluriDivision of Pulmonary, Allergy and Critical Care Medicine and Lung Health Center, University of Alabama at Birmingham, THT 422, 1720, 2nd Avenue South, Birmingham, AL, 35294, USA.
MeiLan K HanDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.
Wassim W LabakiDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.
J Michael WellsDivision of Pulmonary, Allergy and Critical Care Medicine and Lung Health Center, University of Alabama at Birmingham, THT 422, 1720, 2nd Avenue South, Birmingham, AL, 35294, USA.
Fernando J MartinezDivision of Pulmonary and Critical Care Medicine, Weill Cornell School of Medicine, New York, NY, 10065, USA.
R Graham BarrDivision of Pulmonary, Allergy and Critical Care Medicine, Columbia University Medical Center, New York, NY, 10032, USA.
Mark T DransfieldDivision of Pulmonary, Allergy and Critical Care Medicine and Lung Health Center, University of Alabama at Birmingham, THT 422, 1720, 2nd Avenue South, Birmingham, AL, 35294, USA.
SPIROMICS investigators
University of Alabama at Birmingham · USColumbia University Irving Medical Center · USUniversity of Michigan · USCornell University · USUniversity of Alabama at Birmingham Hospital · USUniversity of California System · US

Funding

SPIROMICS II: Biological underpinnings of COPD heterogeneity and progressionU01HL137880 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, PRESCOTT G · 2017 to 2021
$27.9M
SPIROMICS GIC SupportU24HL141762 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J, O'NEAL, WANDA K · 2018 to 2022
$7.2M
Mentoring Research in Precision Medicine for Lung DiseaseK24HL137013 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRESCOTT G WOODRUFF · 2017 to 2026
$1.2M
Diastolic Dysfunction and Pauci-inflammatory Acute Exacerbations of Chronic Obstructive Pulmonary DiseaseK23HL133438 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BHATT, SURYA P. · 2016 to 2020
$921k
Hypercoagulability and Chronic Lung Disease in Older AdultsK23HL130627 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI OELSNER, ELIZABETH · 2016 to 2019
$686k
UAB Mentoring Program in COPD Patient Oriented ResearchK24HL140108 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DRANSFIELD, MARK T · 2018 to 2022
$439k
NHLBI NIH HHS HHSN268200900013CNHLBI NIH HHS HHSN268200900014CNHLBI NIH HHS HHSN268200900015CNHLBI NIH HHS HHSN268200900016CNHLBI NIH HHS HHSN268200900017CNHLBI NIH HHS HHSN268200900018CNHLBI NIH HHS HHSN268200900019CNHLBI NIH HHS HHSN268200900020CNHLBI NIH HHS K23 HL130627NHLBI NIH HHS K23 HL133438NHLBI NIH HHS K23HL133438NHLBI NIH HHS K24 HL137013NHLBI NIH HHS K24 HL140108NHLBI NIH HHS U01 HL137880NHLBI NIH HHS U24 HL141762
6 · The paper itself

Abstract

backgroundChronic obstructive pulmonary disease (COPD) is associated with a two-to-five fold increase in the risk of coronary artery disease independent of shared risk factors. This association is hypothesized to be mediated by systemic inflammation but this link has not been established.

methodsWe included 300 participants enrolled in the SPIROMICS cohort, 75 each of lifetime non-smokers, smokers without airflow obstruction, mild-moderate COPD, and severe-very severe COPD. We quantified emphysema and airway disease on computed tomography, characterized visual emphysema subtypes (centrilobular and paraseptal) and airway disease, and used the Weston visual score to quantify coronary artery calcification (CAC). We used the Sobel test to determine whether markers of systemic inflammation mediated a link between spirometric and radiographic features of COPD and CAC.

resultsFEV

conclusionsThe association between airflow obstruction and coronary calcification is driven primarily by the centrilobular subtype of emphysema, and is linked through bioactive molecules implicated in the pathogenesis of atherosclerosis.

trial registrationClinicalTrials.gov: Identifier: NCT01969344 .

Indexed as

AgedBiomarkersCohort StudiesCoronary Artery DiseaseFemaleHumansInflammation MediatorsMaleMiddle AgedOutcome Assessment, Health CarePulmonary Disease, Chronic ObstructivePulmonary EmphysemaSmokingVascular CalcificationVital CapacityBiomarkersInflammation MediatorsCardiovascular diseaseCOPDCoronary artery calcificationEmphysemaMediators

Identifiers

PMID30563576
PMCPMC6299495
OpenAlexW2904253689

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.