Evidence map›Paper›PMID 30563571›Full record

ArticleCancer imaging : the official publication of the International Cancer Imaging Society2018

"Sentinel lymph node imaging with sequential SPECT/CT lymphoscintigraphy before and after neoadjuvant chemoradiotherapy in patients with cancer of the oesophagus or gastro-oesophageal junction - a pilot study".

Stefan Gabrielson, Jon A Tsai, Fuat Celebioglu, Magnus Nilsson, Ioannis Rouvelas, Mats Lindblad, Annie Bjäreback, Artur Tomson, Rimma Axelsson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer imaging : the official publication of the International Cancer Imaging Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Stefan GabrielsonDepartment of Nuclear Medicine, Karolinska University Hospital, C1-46, SE-141 86 Huddinge, Stockholm, Sweden. stefan.gabrielson@ki.se.ORCID http://orcid.org/0000-0002-8555-4402
Jon A TsaiDepartment of Clinical Science, Intervention and Technology, Division of Surgery, Karolinska Institutet, K53 Huddinge, S-141 86, Stockholm, Sweden.
Fuat CelebiogluDepartment of Clinical Science and Education, Södersjukhuset, Division of Surgery, Sjukhusbacken 10, 118 83, Stockholm, Sweden.
Magnus NilssonDepartment of Clinical Science, Intervention and Technology, Division of Surgery, Karolinska Institutet, K53 Huddinge, S-141 86, Stockholm, Sweden.
Ioannis RouvelasDepartment of Clinical Science, Intervention and Technology, Division of Surgery, Karolinska Institutet, K53 Huddinge, S-141 86, Stockholm, Sweden.
Mats LindbladDepartment of Clinical Science, Intervention and Technology, Division of Surgery, Karolinska Institutet, K53 Huddinge, S-141 86, Stockholm, Sweden.
Annie BjärebackDepartment of Nuclear Medicine, Karolinska University Hospital, C1-46, SE-141 86 Huddinge, Stockholm, Sweden.
Artur TomsonDepartment of Nuclear Medicine, Karolinska University Hospital, C1-46, SE-141 86 Huddinge, Stockholm, Sweden.
Rimma AxelssonDepartment of Nuclear Medicine, Karolinska University Hospital, C1-46, SE-141 86 Huddinge, Stockholm, Sweden.
Karolinska University Hospital · SEKarolinska Institutet · SEStockholm South General Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn current best practise, curatively intended treatment for oesophageal cancer usually consists of neoadjuvant chemo-radiotherapy (nCRT) or perioperative chemotherapy, and oesophagectomy. Sentinel Lymph Node Biopsy (SLNB) has the potential to identify patients without lymph node metastases and thus improve the staging accuracy and influence treatment. The impact of neoadjuvant treatment on the lymphatic drainage of oesophageal cancers and subsequently the SLNB procedure in this tumour type has previously not been well studied. PURPOSE: To evaluate changes in lymphatic drainage patterns of the tumour in patients with cancer of the oesophagus or gastro-oesophageal junction (GOJ) using Sentinel Lymph Node (SLN) hybrid SPECT/CT lymphoscintigraphy before and after nCRT.

methodsPatients with clinical stage T2-T3, any N-stage, M0 cancer of the oesophagus or GOJ underwent endoscopically guided peri-/intratumoral injection of radio-colloid followed by hybrid SPECT/CT lymphoscintigraphy prior to, and once again following, nCRT. SPECT/CT images were evaluated to number and location of SLNs and compared between the two examinations.

resultsTen patients were included in this pilot trial. SPECT/CT lymphoscintigraphy was performed in twenty procedures. The same Sentinel Lymph Node station before and after nCRT was observed in one single patient. In two patients, no SLN was detected before nCRT. In three patients no SLN was detected following nCRT. In four patients, the SLN stations were not the same station at baseline compared to follow-up examination.

conclusionsThe reproducibility SLN detection in patients with cancer of the oesophagus/GOJ following nCRT was very poor. nCRT appears to alter lymphatic drainage patterns and thus may affect detection of SLNs and potentially also the accuracy of an SLNB in these patients. On the basis of these initial results, we abort further patient recruitment in our institution.

trial registrationAustralian New Zealand Clinical Trials Registry (ANZCTR). Identifier ACTRN12618001433291 . Date registered: 27/08/2018. Retrospectively registered.

Indexed as

LymphoscintigraphySingle Photon Emission Computed Tomography Computed TomographyAdultAgedAntineoplastic Combined Chemotherapy ProtocolsChemoradiotherapyCisplatinColloidsEsophageal NeoplasmsEsophagectomyEsophagogastric JunctionEsophagoscopyFemaleFluorouracilHumansInjections, IntralesionalCisplatinColloidsFluorouracilOrganoplatinum CompoundsoxiplatinPyridinesRadiopharmaceuticalsLymphatic structuresNeoadjuvant therapyOesophageal cancerSentinel lymph node conceptSPECT/CT

Identifiers

PMID30563571
PMCPMC6299558
OpenAlexW2904397093

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.