Evidence map›Paper›PMID 30563559›Full record

ArticleArthritis research & therapy2018

Immunosuppressive therapy influences the accelerated age-dependent T-helper cell differentiation in systemic lupus erythematosus remission patients.

Matthias Schaier, Claudius Gottschalk, Lorenz Uhlmann, Claudius Speer, Florian Kälble, Volker Eckstein, Carsten Müller-Tidow, Stefan Meuer, Karsten Mahnke, Hanns-Martin Lorenz and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis research & therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Exhaustion of CD8Frontiers in immunology · 2025
    Article
  2. Sex-specific differences in ICOSClinical and experimental medicine · 2024
    Article
  3. Exhaustion of CD8Frontiers in immunology · 2023
    Article
  4. Review
  5. The RING finger protein family in health and disease.Signal transduction and targeted therapy · 2022
    Review
  6. Article
  7. Impaired Differentiation of Highly Proliferative ICOSInternational journal of molecular sciences · 2021
    Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Matthias SchaierDepartment of Medicine I (Nephrology), University of Heidelberg, Heidelberg, Germany.
Claudius GottschalkDepartment of Obstetrics and Gynaecology, University of Heidelberg, Research Cooperation Unit Gynaecology/Nephrology, INF 162, 69120, Heidelberg, Germany.
Lorenz UhlmannInstitute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany.
Claudius SpeerDepartment of Medicine I (Nephrology), University of Heidelberg, Heidelberg, Germany.
Florian KälbleDepartment of Medicine I (Nephrology), University of Heidelberg, Heidelberg, Germany.
Volker EcksteinDepartment of Medicine V (Haematology, Rheumatology), University of Heidelberg, Heidelberg, Germany.
Carsten Müller-TidowDepartment of Medicine V (Haematology, Rheumatology), University of Heidelberg, Heidelberg, Germany.
Stefan MeuerInstitute of Immunology, University of Heidelberg, Heidelberg, Germany.
Karsten MahnkeDepartment of Dermatology, University of Heidelberg, Heidelberg, Germany.
Hanns-Martin LorenzDepartment of Medicine V (Haematology, Rheumatology), University of Heidelberg, Heidelberg, Germany.
Martin ZeierDepartment of Medicine I (Nephrology), University of Heidelberg, Heidelberg, Germany.
Andrea SteinbornDepartment of Obstetrics and Gynaecology, University of Heidelberg, Research Cooperation Unit Gynaecology/Nephrology, INF 162, 69120, Heidelberg, Germany. andrea.steinborn-kroehl@med.uni-heidelberg.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCD4

methodsTo determine differences in the differentiation of Tregs/Tresps we calculated the percentages of CD45RA

resultsWith age, we found an increased differentiation of RTE Tregs via CD31

conclusionsOur data reveal that the currently used immunosuppressive therapy has a favorable effect on the differentiation and proliferation of Tresps but has a rather unfavorable effect on the proliferation of Tregs. Newer substances with more specific effects on the immune system would be desirable.

Indexed as

AdultAgedAge FactorsCell DifferentiationCell ProliferationCells, CulturedCoculture TechniquesFemaleHumansImmunosuppression TherapyLupus Erythematosus, SystemicLymphocyte ActivationMaleMiddle AgedRemission InductionT-Lymphocytes, Helper-InducerImmunosuppressive therapyProliferation capacityRegulatory T cellsSystemic lupus erythematosusT-helper cell differentiation

Identifiers

PMID30563559
PMCPMC6299578

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.