ArticleMolecular brain2018
Hyperpolarized [1-13C] pyruvate MR spectroscopy detect altered glycolysis in the brain of a cognitively impaired mouse model fed high-fat diet.
Article in Molecular brain, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 23 citations in OpenAlex.
- Hyperpolarized NMR study of the impact of alzheimer's disease on diabetes using a novel rat model.Journal of physiology and biochemistry · 2026Article
- Robust Rapid Cellular Metabolite Sensing Using Benchtop NMR and SABRE-Hyperpolarized [1-Analytical chemistry · 2026Article
- Technologies and Strategies for Metabolic and Molecular Imaging With Hyperpolarized MRI.Journal of magnetic resonance imaging : JMRI · 2026Review
- Scalable Hyperpolarized MRI Enabled by Ace-SABRE of [1-Angewandte Chemie (International ed. in English) · 2025Article
- Time-dependent biphasic alterations in brain metabolism following chronic ketamine exposure in mice.Frontiers in pharmacology · 2025Article
- Awake brain MRSI reveals anesthetic sensitivity and regional aging effects on [Frontiers in neuroimaging · 2025Article
- Western diet increases brain metabolism and adaptive immune responses in a mouse model of amyloidosis.Journal of neuroinflammation · 2024Article
- Inductively coupled, transmit-receive coils for proton MRI and X-nucleus MRI/MRS in small animals.Journal of magnetic resonance open · 2023Article
- Hyperpolarized [1-Yonsei medical journal · 2023Article
- Cognitive dysfunction in diabetes: abnormal glucose metabolic regulation in the brain.Frontiers in endocrinology · 2023Review
- Imaging glucose metabolism to reveal tumor progression.Frontiers in physiology · 2023Review
- A Dual Electrode Biosensor for Glucose and Lactate Measurement in Normal and Prolonged Obese Mice Using Single Drop of Whole Blood.Biosensors · 2021Article
- Imaging Brain Metabolism Using HyperpolarizedTrends in neurosciences · 2020Review
- HyperpolarizedNMR in biomedicine · 2019Article
- Hyperpolarized [1-13C]lactate flux increased in the hippocampal region in diabetic mice.Molecular brain · 2019Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Higher dietary intakes of saturated fatty acid increase the risk of developing Alzheimer's disease and dementia, and even in people without diabetes higher glucose levels may be a risk factor for dementia. The mechanisms causing neuronal dysfunction and dementia by consuming high-fat diet degrading the integrity of the blood-brain barrier (BBB) has been suggested but are not yet fully understood, and metabolic state of the brain by this type of insult is still veiled. The objective of this study was to investigate the effect of high-fat diet on the brain metabolism by a multimodal imaging method using the hyperpolarizedcarbon 13 (
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