Evidence map›Paper›PMID 30563522›Full record

ArticleRespiratory research2018

Predictors of clinical response to extrafine and non-extrafine particle inhaled corticosteroids in smokers and ex-smokers with asthma.

Fajri Gafar, Ilse M Boudewijn, Claire A Cox, Judith M Vonk, Siebrig Schokker, Anne J Lexmond, Henderik W Frijlink, Paul Hagedoorn, Dirkje S Postma, Maarten van den Berge

Open access · goldAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Fajri GafarDepartment of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, PO Box 30.0001, 9700, RB, Groningen, The Netherlands.
Ilse M BoudewijnDepartment of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, PO Box 30.0001, 9700, RB, Groningen, The Netherlands. i.m.boudewijn@umcg.nl.
Claire A CoxDepartment of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, PO Box 30.0001, 9700, RB, Groningen, The Netherlands.
Judith M VonkGroningen Research Institute for Asthma and COPD, University of Groningen, University Medical Center Groningen, PO Box 30.0001, 9700, RB, Groningen, The Netherlands.
Siebrig SchokkerDepartment of Pulmonary Diseases, Martini Hospital Groningen, PO Box 30.033, 9700, RB, Groningen, The Netherlands.
Anne J LexmondDepartment of Pharmaceutical Technology and Biopharmacy, University of Groningen, Antonius Deusinglaan 1, 9713, AV, Groningen, The Netherlands.
Henderik W FrijlinkDepartment of Pharmaceutical Technology and Biopharmacy, University of Groningen, Antonius Deusinglaan 1, 9713, AV, Groningen, The Netherlands.
Paul HagedoornDepartment of Pharmaceutical Technology and Biopharmacy, University of Groningen, Antonius Deusinglaan 1, 9713, AV, Groningen, The Netherlands.
Dirkje S PostmaDepartment of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, PO Box 30.0001, 9700, RB, Groningen, The Netherlands.
Maarten van den BergeDepartment of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, PO Box 30.0001, 9700, RB, Groningen, The Netherlands.
University Medical Center Groningen · NLUniversity of Groningen · NLMartini Ziekenhuis · NL

Funding

Teva Pharmaceutical Industries -
6 · The paper itself

Abstract

We performed a post-hoc analysis of the OLiVIA-study investigating whether current and ex-smoking asthmatics with small airways dysfunction (SAD) show a better response in airway hyperresponsiveness (AHR) to small particle adenosine after treatment with extrafine compared to non-extrafine particle inhaled corticosteroids (ICS), and to investigate which clinical parameters predict a favorable response to both treatments. We show that smoking and ex-smoking asthmatics with and without SAD have a similar treatment response with either extrafine or non-extrafine particle ICS. We also found that lower blood neutrophils are associated with a smaller ICS-response in smokers and ex-smokers with asthma, independent from the level of blood eosinophils.

Indexed as

Ex-SmokersParticle SizeSmokersAdministration, InhalationAdrenal Cortex HormonesAdultAirway RemodelingAnti-Asthmatic AgentsAsthmaEosinophilsFemaleHumansMaleMiddle AgedPredictive Value of TestsSmokingAdrenal Cortex HormonesAnti-Asthmatic AgentsAsthmaExtrafine particleInhaled corticosteroidsNon-extrafine particleSmall airwaysSmoking

Identifiers

PMID30563522
PMCPMC6299530
OpenAlexW2905277269

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.