ArticleBMC psychiatry2018
Association between hyperuricemia and metabolic syndrome in patients suffering from bipolar disorder.
Article in BMC psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 55 citations in OpenAlex.
- Gender Differences in Prevalence and Clinical Correlates of Initial-Treatment and Drug-Naïve Bipolar Disorder Patients With Metabolic Syndrome: A Cross-Sectional Study.Alpha psychiatry · 2025Article
- Association between sleep duration, sleep trouble and all-cause mortality in individuals with hyperuricemia in the United States.Frontiers in public health · 2025Article
- The Prevalence of Hyperuricemia and the Association Between Hyperuricemia and Age in Patients with Psychiatric Disorders to a General Hospital: A Cross-Section Study.International journal of general medicine · 2024Article
- New animal model of chronic gout reproduces pathological features of the disease in humans.RMD open · 2023Article
- Study on association of serum uric acid levels with bipolar disorder: systematic review and meta-analysis in Chinese patients.Annals of general psychiatry · 2023Review
- Association between dietary approaches to stop hypertension (DASH) diet and hyperuricemia among Chinese adults: findings from a nationwide representative study.Nutrition journal · 2023Article
- Prevalence and Risk Factors of Comorbid Obesity in Chinese Patients with Bipolar Disorder.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Metabolomic biomarkers related to non-suicidal self-injury in patients with bipolar disorder.BMC psychiatry · 2022Article
- Article
- High prevalence and low awareness of hyperuricemia in hypertensive patients among adults aged 50-79 years in Southwest China.BMC cardiovascular disorders · 2022Article
- Prevalence and associated factors of obesity and overweight in Chinese patients with bipolar disorder.Frontiers in psychiatry · 2022Article
- The prevalence and associated clinical correlates of hyperuricemia in patients with bipolar disorder.Frontiers in neuroscience · 2022Article
- Clinicopathological characteristics and outcomes of anti-neutrophil cytoplasmic autoantibody-related renal vasculitis with hyperuricemia: a retrospective case-control study.Scientific reports · 2021Article
- Potential Biomarkers for Predicting Depression in Diabetes Mellitus.Frontiers in psychiatry · 2021Article
- Association of serum uric acid levels with suicide risk in female patients with major depressive disorder: a comparative cross-sectional study.BMC psychiatry · 2020Article
- Effects of Lithium Combined with Second-Generation Antipsychotics for the Treatment of Manic Episodes in Patients with Bipolar Disorder: A Naturalistic Study in China.Neuropsychiatric disease and treatment · 2020Article
- Patients With Drug-Naive Bipolar Disorder in Remission After 8 Weeks of Treatment Had Decreased Serum Uric Acid Concentrations.Frontiers in psychiatry · 2019Article
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundClinical studies have shown that bipolar patients have increased serum uric acid levels. High serum uric acid levels could play a role contributing to high prevalence of metabolic syndrome. Metabolic syndrome is known to increase the risk of developing a number of life threatening diseases including coronary heart disease, hypertension, and type 2 diabetes. This study investigated the association between hyperuricemia and metabolic syndrome and its components in individuals suffering from bipolar disorders.
methodsThis study recruited 318 inpatients suffering from bipolar disorders from Beijing Hui-Long-Guan Hospital in China and 160 healthy subjects from the same region as the controls. We used National Cholesterol Education Program Adult Treatment Panel III Adapted criteria (NCEP ATP-III A) for the diagnosis of metabolic syndrome. Hyperuricemia was determined as serum uric acid level above 420 μmol/L in men and 360 μmol/L in women (N Engl J Med 359(17):1811-1821, 2008).
resultsAmong 318 bipolar patients, there was higher prevalence of metabolic syndrome (42.5%) and hyperuricemia (27.7%) than healthy controls (21.9 and 11.9%). Bipolar patients with metabolic syndrome had increased prevalence of hyperuricemia (OR = 3.0, CI95 [1.7-5.4]). Hypertriglyceridemia and larger waist circumference (WC) were associated with hyperunicemia (OR = 1.8, CI95 [1.1-3.1], OR = 1.9, CI95 [1.1-3.4]). Hyperuricemia was associated with metabolic syndrome in bipolar patients (p < 0.001) and especially with hypertriglyceridemia (OR = 1.9, CI95 [1.1-3.1] and increased WC (OR = 2.1 [1.2-4.0]). Bipolar patients over 50 years of age and hyperuricemia were highly prone to develop metabolic syndrome (OR = 14.0, CI95 [5.0-39.0]).
conclusionsHyperuricemia was highly associated with development of metabolic disorder particularly for aged patients suffering from bipolar disorders. Early prevention of hyperuricemia and metabolic syndrome may lead better life for bipolar patients when they get older.
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