Trial reportBMC nephrology2018
Agreement between cystatin-C and creatinine based eGFR estimates after a 12-month exercise intervention in patients with chronic kidney disease.
Trial report in BMC nephrology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 5 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Dietary patterns and physical activity in relation to renal and metabolic outcomes among older adults with type 2 diabetes and chronic kidney disease: a systematic review.Frontiers in nutrition · 2026Pooled it
- The effect of exercise training in people with pre-dialysis chronic kidney disease: a systematic review with meta-analysis.Journal of nephrology · 2024Pooled it
- Interventions for weight loss in people with chronic kidney disease who are overweight or obese.The Cochrane database of systematic reviews · 2021Pooled it
- Effects of exercise on kidney and physical function in patients with non-dialysis chronic kidney disease: a systematic review and meta-analysis.Scientific reports · 2020Pooled it
- Changes in Novel AKI Biomarkers after Exercise. A Systematic Review.International journal of molecular sciences · 2020Pooled it
- Effects of different exercises on renal and cardiovascular function in adult patients with chronic kidney disease not receiving dialysis: a network meta-analysis.BMC nephrology · 2026Article
- Various endurance training intensities improve GFR and Up-regulate AQP2/GSK3β in lithium-induced nephropathic rats.BMC nephrology · 2025Article
- Serum creatinine to cystatin C ratio is a prognostic indicator in esophageal squamous cell carcinoma receiving neoadjuvant immunochemotherapy.Frontiers in immunology · 2025Article
- Serum creatinine, genetic susceptibility, and the risk of osteoporosis and fracture: a prospective cohort study from the UK Biobank.Frontiers in endocrinology · 2025Article
- Exercise-induced changes in intramuscular total creatine concentration measured withPhysiological reports · 2024Article
- Framework of Guidelines for Management of CKD in Asia.Kidney international reports · 2024Article
- Effect of exercise on renal function in diabetic nephropathy-a systematic review and meta-analysis.Journal of Taibah University Medical Sciences · 2023Review
- Correlation of TNF-α, Cys C, and NLRP3 inflammasomes with venous ulcers in patients with lower extremity varicose veins.American journal of translational research · 2023Article
- Glomerular function in relation to fine airborne particulate matter in a representative population sample.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEstimation of GFR (eGFR) using formulae based on serum creatinine concentrations are commonly used to assess kidney function. Physical exercise can increase creatinine turnover and lean mass; therefore, this method may not be suitable for use in exercising individuals. Cystatin-C based eGFR formulae may be a more accurate measure of kidney function when examining the impact of exercise on kidney function. The aim of this study was to assess the agreement of four creatinine and cystatin-C based estimates of GFR before and after a 12-month exercise intervention.
methodsOne hundred forty-two participants with stage 3-4 chronic kidney disease (CKD) (eGFR 25-60 mL/min/1.73 m
resultsControl participants were aged 63.5[9.4] years, 60.3% were male, 42.2% had diabetes, and had an eGFR of 40.5 ± 8.9 ml/min/1.73m
conclusionsIn CKD patients participating in a primarily aerobic based exercise training, without improvements in lean mass, cystatin-C and creatinine based eGFR provided similar estimates of kidney function at both baseline and after 12 months of exercise training.
trial registrationThe trial was registered at www.anzctr.org.au (Registration Number ANZCTR12608000337370) on the 17/07/2008 (retrospectively registered).
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