SynthesisBMC infectious diseases2018
Acute histoplasmosis in immunocompetent travelers: a systematic review of literature.
Synthesis in BMC infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 59 citations in OpenAlex.
- Gastric Involvement With Disseminated Histoplasmosis in an Immunocompetent Patient From a Nonendemic Region.ACG case reports journal · 2026Article
- Histoplasmosis in India: a systematic review of reported cases.Infection · 2026Review
- Histoplasmosis in kidney transplant recipients.BMC nephrology · 2026Review
- Acute histoplasmosis in four immunocompetent Canadian travellers to a cenote in Yucatán, Mexico.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2025Article
- CNS histoplasmosis coexisting with pulmonary tuberculosis in a HIV negative patient: case report.BMC infectious diseases · 2024Article
- Haemophagocytic lymphohistiocytosis secondary to disseminated histoplasmosis in an immunocompetent patient.Medical mycology case reports · 2024Article
- Histoplasmosis peritonitis in an immunocompetent patient: case report.BMC infectious diseases · 2024Article
- The seroprevalence of anti-Histoplasma capsulatum IgG antibody among pulmonary tuberculosis patients in seven referral tuberculosis hospitals in Indonesia.PLoS neglected tropical diseases · 2023Article
- Infection of bats with Histoplasma species.Medical mycology · 2023Review
- Acute pulmonary histoplasmosis: a case series from an outbreak in Southeastern Brazil.Revista do Instituto de Medicina Tropical de Sao Paulo · 2023Article
- Differential diagnosis of pulmonary sarcoidosis: a review.Frontiers in medicine · 2023Review
- Collective outbreak of severe acute histoplasmosis in immunocompetent Chinese in South America: the clinical characteristics and continuous monitoring of serum cytokines/chemokines.BMC primary care · 2022Article
- Pulmonary Histoplasmosis in a Referral Hospital in Mexico City.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2022Article
- CNS Histoplasmosis as a Gliosarcoma mimicker: The diagnostic dilemma of solitary brain lesions.IDCases · 2022Article
- [Puzzling B symptoms in a 61-year-old patient under treatment for rheumatoid arthritis].Der Internist · 2021Article
- Histoplasmosis Diagnosed in Europe and Israel: A Case Report and Systematic Review of the Literature from 2005 to 2020.Journal of fungi (Basel, Switzerland) · 2021Review
- Collecting eco-evolutionary data in the dark: Impediments to subterranean research and how to overcome them.Ecology and evolution · 2021Review
- Autochthonous Case of Pulmonary Histoplasmosis, Switzerland.Emerging infectious diseases · 2021Article
- Subcutaneous Mycoses in Travelers.Current tropical medicine reports · 2020Article
- Difficult to Diagnose: An Unusual Cause of Cavitary Lung Lesion.The American journal of case reports · 2020Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHistoplasmosis is a fungal infection highly endemic in the American continent. The disease can be severe in immunocompromised subjects. In immunocompetent subjects the clinical manifestations are variable. Aim of this work was to review the cases of acute histoplasmosis in immunocompetent travelers reported in literature.
methodsA systematic review of literature was conducted. Electronic search was performed in Pubmed and LILACS. Two reviewers independently extracted data on demographic, clinical and radiological features, and treatment. Cases were classified according to Wheat's definitions.
resultsSeventy-one studies were included in the analysis, comprising a total of 814 patients. Twenty-one patients diagnosed at the Centre of Tropical Diseases, Negrar (VR), Italy were also included. The most common travel destination was Central America (168 people, 29.8%); the most common way of exposure to histoplasma was the exploration of caves and/or contact with bat guano (349 people, 60.9%). The multivariate logistic regression model showed association between the development of disseminated histoplasmosis (DH) and activities that involved the exploration of caves and/or the contact with bats' guano (adjusted OR: 34.20 95% CI: 5.29 to 220.93) or other outdoor activities (adjusted OR: 4.61 95% CI: 1.09 to 19.56). No significant difference in the attack rate between countries of destination was observed (p-value: 0.8906, Kruskal-Wallis test).
conclusionsHistoplasmosis often causes no or mild symptoms in immunocompetent individuals, although a severe syndrome may occur. The infection can mimic other diseases, and the epidemiological risk of exposure is an important clue to raise the index of suspicion.
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