ArticleBMC genomics2018
Multiple trans QTL and one cis-regulatory deletion are associated with the differential expression of cone opsins in African cichlids.
Article in BMC genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Evolutionary dynamics of pre- and postzygotic reproductive isolation in cichlid fishes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Pooled it
- Developing and adult reef fish show rapid light-induced plasticity in their visual system.Molecular ecology · 2023Article
- Evolution of miRNA-Binding Sites and Regulatory Networks in Cichlids.Molecular biology and evolution · 2022Article
- Parallel and population-specific gene regulatory evolution in cold-adapted fly populations.Genetics · 2021Article
- Evolution of regulatory networks associated with traits under selection in cichlids.Genome biology · 2021Article
- Tbx2a Modulates Switching of RH2 and LWS Opsin Gene Expression.Molecular biology and evolution · 2020Article
- Diurnal variation in opsin expression and common housekeeping genes necessitates comprehensive normalization methods for quantitative real-time PCR analyses.Molecular ecology resources · 2019Article
- Chromosome-scale assemblies reveal the structural evolution of African cichlid genomes.GigaScience · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDissecting the genetic basis of phenotypic diversity is one of the fundamental goals in evolutionary biology. Despite growing evidence for gene expression divergence being responsible for the evolution of complex traits, knowledge about the proximate genetic causes underlying these traits is still limited. African cichlids have diverse visual systems, with different species expressing different combinations of seven cone opsin genes. Using opsin expression variation in African cichlids as a model for gene expression evolution, this study aims to investigate the genetic architecture of opsin expression divergence in this group.
resultsResults from a genome-wide linkage mapping on the F
conclusionsDifferential expression of cichlid opsins is associated with multiple overlapping QTL, with all but one in trans to the opsins they regulate. The one cis-acting factor is a deletion in the promoter of the SWS1 opsin, suggesting that ancestral polymorphic deletions may contribute to cichlid's visual diversity. In addition to expanding our understanding of the molecular landscape of opsin expression in African cichlids, this study sheds light on the molecular mechanisms underlying phenotypic variation in natural populations.
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