Evidence map›Paper›PMID 30563405›Full record

ArticleCell cycle (Georgetown, Tex.)2019

HIV-1 Nef promotes cell proliferation and microRNA dysregulation in lung cells.

Maryline Santerre, Wissam Chatila, Ying Wang, Ruma Mukerjee, Bassel E Sawaya

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

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  13. Molecular factors associated with lung cancer in people living with HIV.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Maryline Santerrea Molecular Studies of Neurodegenerative Diseases Lab, FELS Institute for Cancer Research , Lewis Katz School of Medicine, Temple University, Philadelphia , PA , USA.
Wissam Chatilab Departments of Thoracic Medicine and Surgery , Lewis Katz School of Medicine, Temple University, Philadelphia , PA , USA.
Ying Wanga Molecular Studies of Neurodegenerative Diseases Lab, FELS Institute for Cancer Research , Lewis Katz School of Medicine, Temple University, Philadelphia , PA , USA.
Ruma Mukerjeea Molecular Studies of Neurodegenerative Diseases Lab, FELS Institute for Cancer Research , Lewis Katz School of Medicine, Temple University, Philadelphia , PA , USA.
Bassel E Sawayaa Molecular Studies of Neurodegenerative Diseases Lab, FELS Institute for Cancer Research , Lewis Katz School of Medicine, Temple University, Philadelphia , PA , USA.
Temple University · US

Funding

Early Stage Training in the NeurosciencesT32NS076401 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Carol Fuzeti Elias, LESLIE S. SATIN · 2011 to 2026
$3.1M
PGC-1alpha and Reelin: new players in HAND progression.R01AG054411 · NIA · TEMPLE UNIV OF THE COMMONWEALTH · PI SAWAYA, BASSEL E · 2017 to 2021
$2.0M
Involvement of HIV-1 Vpr in neuronal degeneration.R01NS076402 · NINDS · TEMPLE UNIV OF THE COMMONWEALTH · PI SAWAYA, BASSEL E · 2011 to 2015
$1.9M
Role of p53 family in neuropathogenesis in AIDSR01NS059327 · NINDS · TEMPLE UNIV OF THE COMMONWEALTH · PI SAWAYA, BASSEL E · 2008 to 2012
$1.9M
Role of microRNA in HIV associated neurological disorder (HAND).R01MH093331 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI SAWAYA, BASSEL E · 2011 to 2013
$1.1M
NIA NIH HHS R01 AG054411NIMH NIH HHS R01 MH093331NINDS NIH HHS R01 NS059327NINDS NIH HHS R01 NS076402NINDS NIH HHS T32 NS076401
6 · The paper itself

Abstract

Non-small cell lung cancer (NSCLC) represents about 85% of all lung cancer cases. Lung cancer is the most frequent non-AIDS-defining malignancies in HIV-infected patients. The mechanism of the increased risk for lung cancer in HIV-1 patients is poorly understood. HIV-1 Nef protein has been suggested to be one of the key players in HIV-related lung disease. In here, we showed the involvement of Nef protein in cell modifications such as fibroblasts (IMR-90) and normal (BEAS-2B) or cancerous (A549) epithelial cells. We demonstrated that Nef protein reprograms initial stages of lung cancer (e.g. changes in the metabolism, improved cell survival and invasion, increase the angiogenesis factor VEGF). Additionally, we showed that Nef is provoking a global decrease of mature miRNA and a decrease of DICER1 and AGO expression in lung cells. MiRNAs play a crucial role in cell signaling and homeostasis, functioning as oncogenes or tumor suppressors, and their dysregulation can contribute to the tumorigenic process. These results showed that HIV-1 Nef protein is directly involved in preventing cell death and contributes to tumor progression.

Indexed as

Cell ProliferationA549 CellsArgonaute ProteinsAutophagyCarcinoma, Non-Small-Cell LungCell SurvivalDEAD-box RNA HelicasesHIV-1HIV InfectionsHumansLung NeoplasmsMicroRNAsMitochondrianef Gene Products, Human Immunodeficiency VirusRecombinant ProteinsRibonuclease IIIAGO2 protein, humanArgonaute ProteinsDEAD-box RNA HelicasesDICER1 protein, humanMicroRNAsnef Gene Products, Human Immunodeficiency Virusnef protein, Human immunodeficiency virus 1Recombinant ProteinsRibonuclease IIIcell proliferationHuman immunodeficiency virus (HIV)lung cancermicroRNA biogenesismitochondria

Identifiers

PMID30563405
PMCPMC6343720
OpenAlexW2904847704

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.