ArticleJournal of the American Heart Association2019
Negative Affect and Risk of Atrial Fibrillation: MESA.
Article in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 5 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Antidepressant use and the risk of atrial fibrillation and ventricular arrhythmia: A systematic review and meta-analysis.European journal of clinical pharmacology · 2026Pooled it
- Association of Depression, Antidepressants With Atrial Fibrillation Risk: A Systemic Review and Meta-Analysis.Frontiers in cardiovascular medicine · 2022Pooled it
- Associations of Antidepressants With Atrial Fibrillation and Ventricular Arrhythmias: A Systematic Review and Meta-Analysis.Frontiers in cardiovascular medicine · 2022Pooled it
- Psychological aspects of atrial fibrillation: A systematic narrative review : Impact on incidence, cognition, prognosis, and symptom perception.Current cardiology reports · 2020Pooled it
- Relationship between psychological factors and atrial fibrillation: A meta-analysis and systematic review.Medicine · 2020Pooled it
- Mental Health Across the Atrial Fibrillation Continuum: Mechanisms, Outcomes, and Clinical Implications.Life (Basel, Switzerland) · 2026Review
- [The role of psychosocial risk factors in the development and course of atrial fibrillation].Herzschrittmachertherapie & Elektrophysiologie · 2026Review
- Demographic and cardiovascular risk factors associated with blood flow characteristics of the left atrium and left atrial appendage.European radiology · 2026Observational
- Association of self-rated health and risk of incident atrial fibrillation: Findings from three cohorts.American journal of preventive cardiology · 2026Article
- Life course adversity and risk of incident atrial fibrillation: causal mediation analysis of psychological distress in the population-based Tromsø Study.BMJ public health · 2026Article
- Air pollution and cognitive performance in late life: the role of lipid profile - results from the Multi-Ethnic Study of Atherosclerosis (MESA).Environment international · 2025Article
- Debating the link between atrial fibrillation and psychiatric diseases through CaWorld journal of psychiatry · 2025Review
- N-palmitoyl glycine mediates depression-associated atrial fibrillation via Man1a2-dependent autophagy and NRAP dysregulation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Article
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- The Role of Early Risk Factor Modification and Ablation in Atrial Fibrillation Substrate Remodeling Prevention.Biomedicines · 2025Review
- Neuropsychiatry of atrial fibrillation: dementia and beyond.Frontiers in cardiovascular medicine · 2025Review
- Population attributable fraction of total stroke associated with modifiable risk factors in the United States.American journal of epidemiology · 2024Article
- Depression in Cardiac Patients Is a Major Cardiovascular Event Risk Factor: A 12-Month Observational Study.Journal of clinical medicine · 2024Article
- Associations between daytime napping, sleep duration, and depression and 15 cardiovascular diseases: a Mendelian randomization study.Cardiovascular diagnosis and therapy · 2024Article
- The Relationship between Negative Emotions and Atrial Fibrillation: A Mendelian Randomization Study.Reviews in cardiovascular medicine · 2024Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
Background Current literature examining the prospective relationship between depression and other measures of negative affect with atrial fibrillation (AF) are limited. We determined the relationships of depression, anger, anxiety, and chronic stress with incident AF in a multiethnic cohort of middle- and older-aged adults. Methods and Results This analysis included 6644 MESA (Multi-Ethnic Study of Atherosclerosis) study participants who were free of AF at baseline. Depressive symptoms were assessed at baseline and defined as either a 20-item Center for Epidemiologic Studies Depression Scale score ≥16 or use of antidepressant medications. The Spielberger Trait Anger Scale, Spielberger Trait Anxiety Scale, and Chronic Burden Scale were also administered at baseline to assess anger, anxiety, and chronic stress, respectively. The primary outcome was incident AF , identified by follow-up study visit ECGs, hospital discharge diagnoses, or Medicare claims data. A total of 875 (13%) incident AF cases were detected over a median follow-up of nearly 13 years. A Center for Epidemiologic Studies Depression Scale score ≥16 (referent, Center for Epidemiologic Studies Depression Scale score <2) and antidepressant use were associated with a 34% and 36% higher risk of AF , respectively, in separate adjusted Cox proportional hazards analyses (hazard ratio, 1.34; 95% CI 1.04-1.74 for Center for Epidemiologic Studies Depression Scale ≥16; hazard ratio, 1.36; 95% CI , 1.04-1.77 for antidepressant use). No significant associations were observed for anger, anxiety, or chronic stress with development of AF . Conclusions Depressive symptoms are associated with an increased risk of incident AF . Further study into whether improving depressive symptoms reduces AF incidence is important.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.