Evidence map›Paper›PMID 30563388›Full record

SynthesisInterventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences2019

Analysis of revascularisation in ischaemic stroke with EmboTrap (ARISE I study) and meta-analysis of thrombectomy.

Heinrich P Mattle, Carl Scarrott, Mairsil Claffey, John Thornton, Juan Macho, Christian Riedel, Michael Söderman, Alain Bonafé, Michel Piotin, John Newell and 2 more

Registry-linked trialOpen access · greenAbstract readMeta-AnalysisMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02190552 (A.R.I.S.E. Analysis of Revascularisation in Ischemic Stroke With EmboTrap), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02190552 terminatednot on this map

A.R.I.S.E. Analysis of Revascularisation in Ischemic Stroke With EmboTrap: Post Marketing Observational Study of CE Marked EmboTrap Mechanical Thrombectomy Device

TypeobservationalSponsorNeuravi LimitedRan2014 to 2018Enrolled40ConditionsIschemic StrokeArmsEmboTrap® Revascularization Device
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. NIMBUS geometric clot extractor for challenging clots: Real-world clinical experience and clot composition.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
    Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 8 countries.

Heinrich P Mattle1 Department of Neurology, Inselspital, University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0001-7968-1731
Carl Scarrott2 School of Mathematics and Statistics, University of Canterbury, Canterbury, New Zealand.
Mairsil Claffey3 Cerenovus, Galway, Ireland.
John Thornton4 Department of Neuroradiology, Beaumont Hospital, Dublin, Ireland.
Juan Macho5 Hospital Clinico de Barcelona, Barcelona, Spain.
Christian Riedel6 Department of Neuroradiology, University Hospital, Kiel, Germany.
Michael Söderman7 Departments of Neuroradiology and Clinical Neuroscience, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.
Alain Bonafé8 CHU Montpellier, Hôpital Gui de Chauliac, Montpellier, France.
Michel Piotin9 Hôpital Rothschild, Paris, France.ORCID https://orcid.org/0000-0002-1354-4328
John Newell10 School of Mathematics, Statistics and Applied Mathematics, National University of Ireland, Galway, Ireland.
Tommy Andersson7 Departments of Neuroradiology and Clinical Neuroscience, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.
ARISE I Study Group
Karolinska University Hospital · SEBeaumont Hospital · IEHôpital Gui de Chauliac · FRHospital Clínic de Barcelona · ESOllscoil na Gaillimhe – University of Galway · IESorbonne Université · FRUniversity Hospital Schleswig-Holstein · DEUniversity of Bern · CHUniversity of Canterbury · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeThe goal of the analysis of revascularisation in ischaemic stroke with EmboTrap study (ARISE I) was to demonstrate the effectiveness of EmboTrap.

methodsARISE I was an open label, single arm, multicentre, prospective study for the treatment of acute stroke due to large vessel occlusion. The primary outcome was revascularisation of the target vessel as measured by the modified thrombolysis in cerebrovascular infarction (mTICI) score of at least 2b following thrombectomy with EmboTrap. For comparison of the ARISE I results a meta-analysis of eight randomised controlled trials was performed.

resultsARISE I enrolled 40 patients. Their baseline characteristics that are predictors of stroke outcome and procedure timings in ARISE I were similar to those reported in recent randomised controlled trials. The primary outcome, good revascularisation rates (mTICI 2b/3 scores) after three or fewer passes with EmboTrap were 75% (95% confidence interval (CI) 62-88%), which is the same as 74% found in randomised controlled trials (difference of 0.8%, P = 0.95). After additional EmboTrap passes or the use of another device mTICI 2b/3 scores rose to 85% (95% CI 74-96%), which was also similar to the randomised controlled trials (difference 11%, P = 0.38). The high revascularisation rates in ARISE I converted into 64% good clinical outcomes (modified Rankin scale ≤2) compared to 50% in randomised controlled trials (difference 14%; 95% CI -13.7-41.7%; P = 0.32).

conclusionsARISE I demonstrates that thrombectomy using the EmboTrap stent retriever yields similar results to devices that were used in recent randomised controlled trials for the treatment of stroke due to large vessel occlusions. ClinicalTrials.gov identifier NCT02190552.

Indexed as

AdultAgedBrain IschemiaCerebral InfarctionCerebral RevascularizationFemaleHumansMaleMiddle AgedProspective StudiesStentsStrokeThrombectomyTreatment OutcomeIschaemic strokemechanical thrombectomymeta-analysisstent retriever

Identifiers

PMID30563388
PMCPMC6547199
OpenAlexW2904960636

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.