Evidence map›Paper›PMID 30563293›Full record

ArticleMetabolites2018

Reduced Plasma Levels of Very-Long-Chain Dicarboxylic Acid 28:4 in Italian and Brazilian Colorectal Cancer Patient Cohorts.

Paul L Wood, Michelle M Donohue, John E Cebak, Taylor G Beckmann, Márcia Cristina Fernandes Messias, Laura Credidio, Cláudio Saddy Rodrigues Coy, Patrícia de Oliveira Carvalho, Sara Crotti, Sara D'Aronco and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Tryptophan Metabolism as Source of New Prognostic Biomarkers for FAP Patients.International journal of tryptophan research : IJTR · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Paul L WoodMetabolomics Unit, College of Veterinary Medicine, Lincoln Memorial University, 6965 Cumberland Gap Pkwy, Harrogate, TN 37752, USA. paul.wood@lmunet.edu.
Michelle M DonohueMetabolomics Unit, College of Veterinary Medicine, Lincoln Memorial University, 6965 Cumberland Gap Pkwy, Harrogate, TN 37752, USA. michelle.donohue@lmunet.edu.
John E CebakMetabolomics Unit, College of Veterinary Medicine, Lincoln Memorial University, 6965 Cumberland Gap Pkwy, Harrogate, TN 37752, USA. john.cebak@lmunet.edu.
Taylor G BeckmannDepartment of Medicine, DeBusk College of Osteopathic Medicine, Lincoln Memorial University, 6965 Cumberland Gap Pkwy., Harrogate, TN 37752, USA. taylor.beckmann@lmunet.edu.
Márcia Cristina Fernandes MessiasLaboratory of Multidisciplinary Research, São Francisco University (USF), Bragança Paulista, São Paulo 12916-900, Brazil. marcia_cfmessias@hotmail.com.
Laura CredidioDepartment of Surgery, University of Campinas (UNICAMP), Campinas, São Paulo 12916-900, Brazil. laurabio@gmail.com.
Cláudio Saddy Rodrigues CoyDepartment of Surgery, University of Campinas (UNICAMP), Campinas, São Paulo 12916-900, Brazil. claudiocoy@gmail.com.
Patrícia de Oliveira CarvalhoLaboratory of Multidisciplinary Research, São Francisco University (USF), Bragança Paulista, São Paulo 12916-900, Brazil. patricia.carvalho@usf.edu.br.
Sara CrottiNano-Inspired Biomedicine Lab, Istituto di Ricerca Pediatrica-Città della Speranza, 35127 Padua, Italy. s.crotti@irpcds.org.
Sara D'AroncoNano-Inspired Biomedicine Lab, Istituto di Ricerca Pediatrica-Città della Speranza, 35127 Padua, Italy. edl.urso@unipd.it.
Emanuele D L UrsoFirst Surgery Clinic, Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, Padua 35128, Italy. edl.urso@unipd.it.
Marco AgostiniNano-Inspired Biomedicine Lab, Istituto di Ricerca Pediatrica-Città della Speranza, 35127 Padua, Italy. m.agostini@unipd.it.
Lincoln Memorial University · USCittà della Speranza Foundation · ITUniversidade Estadual de Campinas (UNICAMP) · BRUniversidade São Francisco · BRUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere are currently no blood-based biomarkers for early diagnosis of colorectal cancer. Previous research has suggested that very-long-chain dicarboxylic acid (VLCDCA) 28:4 might be such a biomarker.

methodsUsing high-resolution mass spectrometry, we analyzed VLCDCA 28:4 in the plasma of colorectal cancer patients in Italian [

conclusionsThe plasma levels of VLCDCA 28:4 represent a potential biomarker of sporadic colorectal cancer. In addition, it is possible that resupply of this anti-inflammatory lipid may represent a new therapeutic strategy for CRC and inflammatory disorders.

Indexed as

cancer biomarkercolorectal cancerfamilial adenomatous polyposishigh-resolution mass spectrometryinflammationvery-long-chain dicarboxylic acid 28:4

Identifiers

PMID30563293
PMCPMC6316647
OpenAlexW2902859618

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.