ArticleSensors (Basel, Switzerland)2018
Etched Fiber Bragg Grating Biosensor Functionalized with Aptamers for Detection of Thrombin.
Article in Sensors (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 93 citations in OpenAlex.
- Periodontal Disease Diagnosis by a Chemically Etched Single-Mode Fiber-Optic Biosensor for Label-Free Detection of Matrix Metalloproteinase-8 (MMP-8).Biosensors · 2026Article
- Surface-Modified Extrinsic Semi-Distributed Interferometers for Fiber-Optic Refractive Index Detection and Biosensing.Biosensors · 2026Article
- Fiber ring laser biosensor based on no-core fibers for label-free DNA biomolecule measurements.RSC advances · 2025Article
- All-fiber label-free optical fiber biosensors: from modern technologies to current applications [Invited].Biomedical optics express · 2024Review
- Optical fiber surface plasmon resonance sensor using electroless-plated gold film for thrombin detection.Analytical and bioanalytical chemistry · 2024Article
- Functionalized optical fiber ball-shaped biosensor for label-free, low-limit detection of IL-8 protein.Biomedical optics express · 2024Article
- Progress and Trends of Optical Microfiber-Based Biosensors.Biosensors · 2023Review
- A Fiber Bragg Grating Sensor Based on Cladding Mode Resonance for Label-Free Biosensing.Biosensors · 2023Article
- Long-Period Fiber Grating Sensors for Chemical and Biomedical Applications.Sensors (Basel, Switzerland) · 2023Review
- Review
- A review of Optical Point-of-Care devices to Estimate the Technology Transfer of These Cutting-Edge Technologies.Biosensors · 2022Review
- Cost-Effective Fiber Optic Solutions for Biosensing.Biosensors · 2022Review
- Optimization of Cladding Diameter for Refractive Index Sensing in Tilted Fiber Bragg Gratings.Sensors (Basel, Switzerland) · 2022Article
- Relevance of the Spectral Analysis Method of Tilted Fiber Bragg Grating-Based Biosensors: A Case-Study for Heart Failure Monitoring.Sensors (Basel, Switzerland) · 2022Article
- Design and Manufacturing Optoelectronic Sensors for the Measurement of Refractive Index Changes under Unknown Polarization State.Sensors (Basel, Switzerland) · 2021Article
- Optical Fiber Ball Resonator Sensor Spectral Interrogation through Undersampled KLT: Application to Refractive Index Sensing and Cancer Biomarker Biosensing.Sensors (Basel, Switzerland) · 2021Article
- Label-free fiber-optic spherical tip biosensor to enable picomolar-level detection of CD44 protein.Scientific reports · 2021Article
- Shallow-Tapered Chirped Fiber Bragg Grating Sensors for Dual Refractive Index and Temperature Sensing.Sensors (Basel, Switzerland) · 2021Article
- Perspectives on Assembling Coronavirus Spikes on Fiber Optics to Reveal Broadly Recognizing Antibodies and Generate a Universal Coronavirus Detector.Frontiers in bioengineering and biotechnology · 2021Article
- Recent Advances in Electrochemical Sensors for the Detection of Biomolecules and Whole Cells.Biomedicines · 2020Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
A biosensor based on an etched Fiber Bragg Grating (EFBG) for thrombin detection is reported. The sensing system is based on a Fiber Bragg Grating (FBG) with a Bragg wavelength of 1550 nm, wet-etched in hydrofluoric acid (HF) for ~27 min, to achieve sensitivity to a refractive index (RI) of 17.4 nm/RIU (refractive index unit). Subsequently, in order to perform a selective detection of thrombin, the EFBG has been functionalized with silane-coupling agent 3-(aminopropyl)triethoxysilane (APTES) and a cross-linker, glutaraldehyde, for the immobilization of thrombin-binding aptamer. The biosensor has been validated for thrombin detection in concentrations ranging from 10 nM to 80 nM. The proposed sensor presents advantages with respect to other sensor configurations, based on plasmonic resonant tilted FBG or Long Period Grating (LPG), for thrombin detection. Firstly, fabricating an EFBG only requires chemical etching. Moreover, the functionalization method used in this study (silanization) allows the avoidance of complicated and expensive fabrications, such as thin film sputtering or chemical vapor deposition. Due to their characteristics, EFBG sensors are easier to multiplex and can be used in vivo. This opens new possibilities for the detection of thrombin in clinical settings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.