Evidence map›Paper›PMID 30563203›Full record

ArticleInternational journal of molecular sciences2018

Dysregulation of Lipid Metabolism in Mkp-1 Deficient Mice during Gram-Negative Sepsis.

Jinhui Li, Xiantao Wang, William E Ackerman, Abel J Batty, Sean G Kirk, William M White, Xianxi Wang, Dimitrios Anastasakis, Lobelia Samavati, Irina Buhimschi and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Cellular and Exosomal Regulations of Sepsis-Induced Metabolic Alterations.International journal of molecular sciences · 2021
    Review
  8. Knockout of MAPK Phosphatase-1 Exaggerates Type I IFN Response during SystemicJournal of immunology (Baltimore, Md. : 1950) · 2021
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Dual-Specificity Phosphatases in Immunity and Infection: An Update.International journal of molecular sciences · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Jinhui LiCenter for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43215, USA. jinhui.liu@nationwidechildrens.org.
Xiantao WangLaboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Disease, National Institutes of Health, Bethesda, MD 20892, USA. xiantao.wang@nih.gov.
William E AckermanDepartment of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus, OH 43210, USA. William.Ackerman@nationwidechildrens.org.
Abel J BattyCenter for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43215, USA. Abel.Batty@nationwidechildrens.org.
Sean G KirkCenter for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43215, USA. Sean.Kirk@nationwidechildrens.org.
William M WhiteCenter for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43215, USA. white.2729@buckeyemail.osu.edu.
Xianxi WangCenter for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43215, USA. xianxi.wang@nationwidechildrens.org.
Dimitrios AnastasakisLaboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Disease, National Institutes of Health, Bethesda, MD 20892, USA. dimitrios.anastasakis@nih.gov.ORCID 0000-0003-2306-275X
Lobelia SamavatiCenter for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA. lsamavat@med.wayne.edu.ORCID 0000-0002-3327-2585
Irina BuhimschiCenter for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43215, USA. Irina.Buhimschi@nationwidechildrens.org.ORCID 0000-0002-1701-1326
Leif D NelinCenter for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43215, USA. leif.nelin@nationwidechildrens.org.
Markus HafnerLaboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Disease, National Institutes of Health, Bethesda, MD 20892, USA. markus.hafner@nih.gov.ORCID 0000-0002-4336-6518
Yusen LiuCenter for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43215, USA. yusen.liu@nationwidechildrens.org.
Nationwide Children's Hospital · USNational Institutes of Health · USThe Ohio State University · USWayne State University · US

Funding

Integration of the results from systems-level determination of cis-acting elements into high-resolution maps of posttranscriptional regulatory events.ZIAAR041205 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI HAFNER, MARKUS · 2016 to 2025
$5.5M
Regulation and Function of Mkp-1 During Sepsis.R01AI124029 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI LIU, YUSEN · 2017 to 2021
$1.9M
National Institutes of Health R01 AI68956, R01 AI124029, and R01 HL113508NIAID NIH HHS R01 AI124029
6 · The paper itself

Abstract

Mitogen-activated protein kinase phosphatase (Mkp)-1 exerts its anti-inflammatory activities during Gram-negative sepsis by deactivating p38 and c-Jun N-terminal kinase (JNK). We have previously shown that

Indexed as

Lipid MetabolismAnimalsDual Specificity Phosphatase 1Escherichia coli InfectionsGene Expression ProfilingGene Expression RegulationHigh-Throughput Nucleotide SequencingLiverMetabolic Networks and PathwaysMiceSepsisSequence Analysis, RNATriglyceridesDual Specificity Phosphatase 1Dusp1 protein, mouseTriglyceridesE. coli infectionhypertriglyceridemialiver steatosisMkp-1sepsis

Identifiers

PMID30563203
PMCPMC6321205
OpenAlexW2903214824

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.