SynthesisNutrients2018
Selenium and Type 2 Diabetes: Systematic Review.
Synthesis in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 92 citations in OpenAlex.
- Impact of organic selenium supplementation on glycaemic control and quality of life in patients with diabetic neuropathy: a randomized placebo-controlled trial.European journal of nutrition · 2026Trial
- The effect of a comprehensive intervention on anthropometric indices, dietary intake, and physical activity of adolescent boys with overweight.BMC pediatrics · 2025Trial
- Effect of selenium supplementation on musculoskeletal health in older women: a randomised, double-blind, placebo-controlled trial.The lancet. Healthy longevity · 2021Trial
- Trace Elements in the Pancreas: From Physiological Homeostasis to the Pathogenesis of Diabetes, Pancreatitis, and Cancer-A Review.Life (Basel, Switzerland) · 2026Review
- Applications of Nano-Selenium in the Poultry Industry: An Overview.Nanomaterials (Basel, Switzerland) · 2026Review
- Selenium-enrichedFrontiers in fungal biology · 2026Article
- Selenium status markers and their relationship with anthropometric, glycemic, and inflammatory variables in institutionalized older adults.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Article
- Activation of the De Novo Serine Synthesis Pathway and Disruption of Insulin Signaling Induced by Supplemental SeMet in Vitro.Biological trace element research · 2025Article
- The association between type 2 diabetes and dietary antioxidant index: a cross-sectional study in the Iranian population.Archives of endocrinology and metabolism · 2025Article
- Obesity, composite dietary antioxidant index, and their interactive association with the risk of cardiometabolic multimorbidity in the elderly from a large national survey.Lipids in health and disease · 2025Article
- Association of Dietary Selenium Intake with Type 2 Diabetes in Middle-Aged and Older Adults in China.Nutrients · 2024Article
- Understanding the Roles of Selenium on Thyroid Hormone-Induced Thermogenesis in Adipose Tissue.Biological trace element research · 2024Review
- A prospective association between dietary mushroom intake and the risk of type 2 diabetes: the Korean Genome and Epidemiology Study-Cardiovascular Disease Association Study.Epidemiology and health · 2024Article
- A Comprehensive Review on GLP-1 Signaling Pathways in the Management of Diabetes Mellitus - Focus on the Potential Role of GLP-1 Receptors Agonists and Selenium among Various Organ Systems.Current diabetes reviews · 2024Review
- Effects of Gestational Diabetes Mellitus and Selenium Deficiency on the Offspring Growth and Blood Glucose Mechanisms of C57BL/6J Mice.Nutrients · 2023Article
- Composite dietary antioxidant index was negatively associated with the prevalence of diabetes independent of cardiovascular diseases.Diabetology & metabolic syndrome · 2023Article
- Antimicrobial and anti-viral effects of selenium nanoparticles and selenoprotein based strategies: COVID-19 and beyond.Journal of drug delivery science and technology · 2023Review
- The Role of Selenium and Manganese in the Formation, Diagnosis and Treatment of Cervical, Endometrial and Ovarian Cancer.International journal of molecular sciences · 2023Review
- Latent Potential of Multifunctional Selenium Nanoparticles in Neurological Diseases and Altered Gut Microbiota.Materials (Basel, Switzerland) · 2023Review
- Selenium - a scoping review for Nordic Nutrition Recommendations 2023.Food & nutrition research · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
Several studies have investigated the potential role of selenium (Se) in the development of type 2 diabetes (T2D) with disparate findings. We conducted a systematic review and meta-analysis to synthesize the evidence of any association between Se and T2D. PubMed, Embase, and Scopus were searched following the Preferred Reporting Items for Systematic Reviews and Meta-analysis Approach (PRISMA). Sixteen studies from 15 papers met inclusion criteria defined for this review. Of the 13 observational studies included, 8 demonstrated a statistically significant positive association between concentrations of Se and odds for T2D, with odds ratios (95% confidence intervals) ranging from 1.52 (1.01⁻2.28) to 7.64 (3.34⁻17.46), and a summary odds ratio (OR) (95% confidence interval (CI)) of 2.03 (1.51⁻2.72). In contrast, among randomized clinical trials (RCTs) of Se, a higher risk of T2D was not observed for those who received Se compared to a placebo (OR = 1.18, 95% CI 0.95⁻1.47). Taken together, the results for the relationship between Se and T2D differ between observational studies and randomized clinical trials (RCTs). It remains unclear whether these differences are the result of uncontrolled confounding in the observational studies, or whether there is a modest effect of Se on the risk for T2D that may vary by duration of exposure. Further investigations on the effects of Se on glucose metabolism are needed.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.