Evidence map›Paper›PMID 30563115›Full record

ArticleJournal of clinical medicine2018

Prior Use of Antiplatelet Therapy and Outcomes after Endovascular Therapy in Acute Ischemic Stroke Due to Large Vessel Occlusion: A Single-Center Experience.

Giovanni Merlino, Massimo Sponza, Gian Luigi Gigli, Simone Lorenzut, Alessandro Vit, Vladimir Gavrilovic, Andrea Pellegrin, Daniela Cargnelutti, Mariarosaria Valente

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 28 citations in OpenAlex.

  1. Prior antiplatelet therapy in patients undergoing endovascular treatment for acute ischemic stroke: Results from the MR CLEAN Registry.International journal of stroke : official journal of the International Stroke Society · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Giovanni MerlinoStroke Unit, Department of Neurosciences, Udine University Hospital, 33100 Udine, Italy. giovanni.merlino@asuiud.sanita.fvg.it.
Massimo SponzaDivision of Vascular and Interventional Radiology, Udine University Hospital, 33100 Udine, Italy. massimo.sponza@asuiud.sanita.fvg.it.
Gian Luigi GigliNeurology Unit, Department of Medical, University of Udine Medical School, 33100 Udine, Italy. gigli@uniud.it.
Simone LorenzutStroke Unit, Department of Neurosciences, Udine University Hospital, 33100 Udine, Italy. simone.lorenzut@asuiud.sanita.fvg.it.
Alessandro VitDivision of Vascular and Interventional Radiology, Udine University Hospital, 33100 Udine, Italy. alessandro.vit@asuiud.sanita.fvg.it.
Vladimir GavrilovicDivision of Vascular and Interventional Radiology, Udine University Hospital, 33100 Udine, Italy. vladimir.gavrilovic@asuiud.sanita.fvg.it.
Andrea PellegrinDivision of Vascular and Interventional Radiology, Udine University Hospital, 33100 Udine, Italy. andrea.pellegrin@asuiud.sanita.fvg.it.
Daniela CargneluttiStroke Unit, Department of Neurosciences, Udine University Hospital, 33100 Udine, Italy. daniela.cernelutti@asuiud.sanita.fvg.it.
Mariarosaria ValenteNeurology Unit, Department of Medical, University of Udine Medical School, 33100 Udine, Italy. valente@uniud.it.
University of Udine · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endovascular therapy (EVT) represents the gold standard treatment in patients affected by acute ischemic stroke (AIS) due to large vessel occlusion (LVO). Prior antiplatelet (APT) therapy might increase the risk of bleeding and modify the clinical outcome of AIS patients treated with EVT. Thus, we compared effectiveness and safety of EVT in Caucasian patients with and without previous use of APT agents. We recruited consecutive patients admitted to Udine University Hospital with AIS undergoing EVT from January 2015 to December 2017. The following outcomes were documented: successful recanalization, 3-month favorable outcome, symptomatic intracranial hemorrhage (sICH), parenchymal hematoma (PH), and 3-month mortality. The study population included 100 patients (mean age 70.1 ± 11.2 years, 58% males). At time of admission, 34 patients were taking APT agents. Patients on APT pretreatment were older, had more vascular risk factors, and showed higher levels of serum creatinine than APT naïve patients. Moreover, prior APT therapy was associated with a higher rate of pre-stroke disability and a more severe stroke at admission. Patients pretreated with APT had higher rates of successful recanalization (91.2% vs. 74.2%,

Indexed as

antiplatelet therapybridging therapymortalityoutcomesymptomatic intracranial hemorrhagethrombectomy

Identifiers

PMID30563115
PMCPMC6307087
OpenAlexW2903446672

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.