ReviewThe ocular surface2019
Characterization of the thickness of the tear film lipid layer using high resolution microscopy.
Review in The ocular surface, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- A Controlled-Area Droplet Evaporimeter Reveals Surface Pressure-Dependent Evaporation Resistance of the Tear Film Lipid Layer.Investigative ophthalmology & visual science · 2026Article
- Imaging Approaches for the Diagnosis of Dry Eye: A Review.Diagnostics (Basel, Switzerland) · 2026Review
- Development and multicenter validation of an AI driven model for quantitative meibomian gland evaluation.NPJ digital medicine · 2025Article
- Tear film assessment before and after phacoemulsification in patients with age-related cataracts.BMC ophthalmology · 2024Observational
- A comparative study on the lipid layer thickness analysis of medical staff before and after work.PeerJ · 2024Article
- Patient Satisfaction and Tear Film Break-Up Time After First-Time Wearing of Silicone Hydrogel Contact Lenses.Cureus · 2024Article
- Biomimetic-Engineered Silicone Hydrogel Contact Lens Materials.ACS applied bio materials · 2023Review
- Remote Measurements of Tear Electrolyte Concentrations on Both Sides of an Inserted Contact Lens.Chemosensors (Basel, Switzerland) · 2023Article
- Differential characteristics among asymptomatic and symptomatic meibomian gland dysfunction and those with dry eye.BMC ophthalmology · 2023Article
- Effect of Model Tear Film Lipid Layer on Water Evaporation.Investigative ophthalmology & visual science · 2023Article
- No Evidence of Induced Skin Cancer or Other Skin Abnormalities after Long-Term (66 week) Chronic Exposure to 222-nm Far-UVC Radiation.Photochemistry and photobiology · 2023Article
- Pre-Lens Tear Meniscus Height, Lipid Layer Pattern and Non-Invasive Break-Up Time Short-Term Changes with a Water Gradient Silicone Hydrogel Contact Lens.Life (Basel, Switzerland) · 2022Article
- Characterization of the thickness of the Tear Film Lipid Layer in Meibomian Gland Dysfunction using high resolution optical microscopy.The ocular surface · 2022Article
- Validation of a new objective method to assess lipid layer thickness without the need of an interferometer.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022Article
- Human ocular mucins: The endowed guardians of sight.Advanced drug delivery reviews · 2022Review
- In vivo thickness measurement of the lipid layer and the overall tear film by interferometry.Optics letters · 2019Article
- Evaluation of lipid layer tear film changes after femtosecond small incision lenticule extraction.Therapeutic advances in ophthalmologyArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Interferometry is an optical technique that have been used to quantify the lipid layer of the precorneal tear film, and to investigate the relationship between lipid layer thickness and tear film evaporation. However, the relationship between lipid layer thickness and the rate of evaporation is far from consistent. One possible reason is the inherent limit of contemporary interferometric systems, which employ objectives with relatively long depth of focus (DOF) (>15 μm or more), which tend to collect excessive extra-planar noise. This limitation may negatively affect the accuracy of the characterization and thickness measurement of the lipid layer. The current system incorporated an objective with limited DOF (∼1.5 μm) into a custom-built optical microscope to image the tear film lipid layer in humans. An algorithm was also developed to process these images. One major outcome of this system is that thick lipid layers exhibit higher variation in thickness values than thin or normal-thickness lipid layers. The variations may reflect the structural differences of the lipid layer, which may offer a novel dimension to explain the missing correlation between lipid layer thickness and evaporation. In summary, the development of the high resolution microscopy system and associated data processing algorithm may provide new insights into the lipid layer structure, topography and their relation to the tear film evaporation rate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.