ArticleNeurobiology of learning and memory2019
Coupling of autonomic and central events during sleep benefits declarative memory consolidation.
Article in Neurobiology of learning and memory, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Sleep and cardiac autonomic modulation in older adults: Insights from an at-home study with auditory deep sleep stimulation.Journal of sleep research · 2025Trial
- Trial
- Article
- Autonomic Gating of Ripple Mode Selection at Sleep Onset.Neuroscience bulletin · 2026Article
- Noradrenergic infraslow rhythm during sleep is the critical link between heart-rate dynamics and memory consolidation.bioRxiv : the preprint server for biology · 2026Article
- Tone-Evoked Sleep Electroencephalographic Slow Oscillations as a Function of Peripheral Rhythms: New Insights Into the Brain-Heart Integration.Journal of sleep research · 2026Article
- Effect of Ventilation on Physiological Recovery During Midday Naps: A Heart Rate Variability Analysis of Office Workers.Sensors (Basel, Switzerland) · 2026Article
- Cross-modal synchronization of EEG and ECG reveals hidden signatures of recovery in traumatic brain injury.Journal of neuroengineering and rehabilitation · 2026Article
- MRI methods for the study of central nervous system involvement in autonomic function.Frontiers in network physiology · 2026Review
- Monitoring and modulating interconnected physiological systems in space using portable closed-loop technologies.Frontiers in network physiology · 2026Article
- A user's introduction to an algorithmic method to identify space-time profiles of sleep slow oscillations: dataset constraints, case-use examples, and open-source code.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Sleep neuroimaging: Review and future directions.Journal of sleep research · 2025Review
- Pupil size reveals arousal level fluctuations in human sleep.Nature communications · 2025Article
- REM refines and rescues memory representations: a new theory.Sleep advances : a journal of the Sleep Research Society · 2025Review
- Peripheral blood flow estimated by laser doppler flowmetry provides additional information about sleep state beyond that provided by pulse rate variability.Frontiers in physiology · 2023Article
- Understanding the roles of central and autonomic activity during sleep in the improvement of working memory and episodic memory.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Cardiac sympathetic-vagal activity initiates a functional brain-body response to emotional arousal.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Co-ordination of brain and heart oscillations during non-rapid eye movement sleep.Journal of sleep research · 2022Article
- Effects of 24-h acute total sleep deprivation on physiological coupling in healthy young adults.Frontiers in neuroscience · 2022Article
- Global and non-Global slow oscillations differentiate in their depth profiles.Frontiers in network physiology · 2022Article
Corrections and comments
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Authors and funding
5 authors.
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Abstract
While anatomical pathways between forebrain cognitive and brainstem autonomic nervous centers are well-defined, autonomic-central interactions during sleep and their contribution to waking performance are not understood. Here, we analyzed simultaneous central activity via electroencephalography (EEG) and autonomic heart beat-to-beat intervals (RR intervals) from electrocardiography (ECG) during wake and daytime sleep. We identified bursts of ECG activity that lasted 4-5 s and predominated in non-rapid-eye-movement sleep (NREM). Using event-based analysis of NREM sleep, we found an increase in delta (0.5-4 Hz) and sigma (12-15 Hz) power and an elevated density of slow oscillations (0.5-1 Hz) about 5 s prior to peak of the heart rate burst, as well as a surge in vagal activity, assessed by high-frequency (HF) component of RR intervals. Using regression framework, we show that these Autonomic/Central Events (ACE) positively predicted post-nap improvement in a declarative memory task after controlling for the effects of spindles and slow oscillations from sleep periods without ACE. No such relation was found between memory performance and a control nap. Additionally, NREM ACE negatively correlated with REM sleep and learning in a non-declarative memory task. These results provide the first evidence that coordinated autonomic and central events play a significant role in declarative memory consolidation.
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