ArticleAmerican journal of physiology. Endocrinology and metabolism2019
Youth with type 2 diabetes have hepatic, peripheral, and adipose insulin resistance.
Article in American journal of physiology. Endocrinology and metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- The epidemiology of metabolic dysfunction-associated steatotic liver disease among pediatric patients with type 2 diabetes: Systematic review and meta-analysis.European journal of pediatrics · 2026Pooled it
- Glycemia and Gluconeogenesis With Metformin and Liraglutide: A Randomized Trial in Youth-onset Type 2 Diabetes.The Journal of clinical endocrinology and metabolism · 2024Trial
- The obesity paradox: Retinopathy, obesity, and circulating risk markers in youth with type 2 diabetes in the TODAY Study.Journal of diabetes and its complications · 2022Trial
- Youth-Onset Type 2 Diabetes: What We've Learned From Key Youth-Onset Type 2 Diabetes Studies, What We Still Don't Know, and Why It Is Important.Diabetes care · 2025Review
- Metabolic clearance rate of insulin across the glucose tolerance spectrum by race and ethnicity in youth with obesity.Obesity (Silver Spring, Md.) · 2025Article
- Racial and ethnic sleep health disparities in adolescents and risk for type 2 diabetes: a narrative review.Annals of medicine · 2024Review
- Reduced Growth Hormone Predicts Worsening Adipose Tissue Insulin Resistance in Adults with Obesity.Obesity facts · 2023Article
- Correspondence on Editorial regarding "Screening and prediction of nonalcoholic fatty liver disease using a peripheral insulin resistance index: Potential benefits and limitations".Clinical and molecular hepatology · 2023Article
- Spectrum of Phenotypes and Causes of Type 2 Diabetes in Children.Annual review of medicine · 2022Review
- Mathematical modeling reveals differential dynamics of insulin action models on glycerol and glucose in adolescent girls with obesity.Frontiers in physiology · 2022Article
- Oral minimal model-based estimates of insulin sensitivity in obese youth depend on oral glucose tolerance test protocol duration.Metabolism open · 2021Article
- Time limited eating in adolescents with obesity (time LEAd): Study protocol.Contemporary clinical trials · 2020Article
- The changing face of paediatric diabetes.Diabetologia · 2020Review
- Advances in stable isotope tracer methodology part 1: hepatic metabolism via isotopomer analysis and postprandial lipolysis modeling.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2020Article
- Muscle Insulin Resistance in Youth with Obesity and Normoglycemia is Associated with Altered Fat Metabolism.Obesity (Silver Spring, Md.) · 2019Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Adolescents with type 2 diabetes (T2D) have severe insulin resistance (IR) secondary to obesity, genetics, and puberty, and IR predicts metabolic comorbidities. Adults with T2D have multitissue IR, which has guided therapeutic developments, but this is not established in youth. We sought to assess adipose, hepatic, and peripheral insulin sensitivity in adolescents with and without T2D. Twenty-seven youth with T2D [age: 15.6 ± 0.4 yr; female: 78%; body mass index (BMI) percentile: 96.1 (52.6, 95.9), late puberty; hemoglobin A1c (HbA1c) 7.3% (6.2, 10.1)] and 21 controls of similar BMI, pubertal stage, and habitual activity were enrolled. Insulin action was measured with a four-phase hyperinsulinemic-euglycemic clamp (basal, 10, 16, and 80 mU·m
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