Evidence map›Paper›PMID 30562058›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2019

Arsenic modifies serotonin metabolism through glucuronidation in pancreatic β-cells

Christopher M Carmean, Norihide Yokoi, Harumi Takahashi, Okechi S Oduori, Christie Kang, Akiko Kanagawa, Andrew G Kirkley, Guirong Han, Michael Landeche, Shihomi Hidaka and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Christopher M CarmeanDivision of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine , Kobe , Japan.ORCID 0000-0001-7662-9946
Norihide YokoiDivision of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine , Kobe , Japan.
Harumi TakahashiDivision of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine , Kobe , Japan.
Okechi S OduoriDivision of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine , Kobe , Japan.
Christie KangDepartment of Pathology, College of Medicine, University of Illinois at Chicago , Chicago, Illinois.
Akiko KanagawaDivision of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine , Kobe , Japan.
Andrew G KirkleyCommittee on Molecular Pathogenesis and Molecular Medicine, University of Chicago , Chicago, Illinois.
Guirong HanDivision of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine , Kobe , Japan.
Michael LandecheDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, College of Medicine, University of Illinois at Chicago , Chicago, Illinois.
Shihomi HidakaDivision of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine , Kobe , Japan.
Miki KatohDepartment of Pharmaceutics, Faculty of Pharmacy, Meijo University , Nagoya , Japan.
Robert M SargisDepartment of Pathology, College of Medicine, University of Illinois at Chicago , Chicago, Illinois.
Susumu SeinoDivision of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine , Kobe , Japan.
Kansai Electric Power (Japan) · JPKobe University · JPUniversity of Illinois Chicago · USMeijo University · JPUniversity of Chicago · US

Funding

TRANSGENIC COREP60DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI BELL, GRAEME I · 1985 to 2012
$25.5M
Pilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI Matthew J Brady · 2013 to 2026
$20.9M
Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
Selenoproteins in Arsenic-Induced Metabolic DysfunctionR01ES028879 · NIEHS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SARGIS, ROBERT M · 2018 to 2022
$2.7M
NIDDK NIH HHS P30 DK020595NIDDK NIH HHS P60 DK020595NIEHS NIH HHS P30 ES027792NIEHS NIH HHS R01 ES028879
6 · The paper itself

Abstract

In arsenic-endemic regions of the world, arsenic exposure correlates with diabetes mellitus. Multiple animal models of inorganic arsenic (iAs, as As

Indexed as

5-HydroxytryptophanAdultAnimalsArsenicCell LineDiabetes MellitusFemaleGene Knockdown TechniquesGlucoseGlucuronosyltransferaseHumansInsulin-Secreting CellsInsulin SecretionIslets of LangerhansMaleMice5-HydroxytryptophanArsenicGlucoseGlucuronosyltransferaseRNA, MessengerSerotoninUDP-glucuronosyltransferase 1a6a, mousearsenicdiabetesglucuronidationinsulin secretionserotonin

Identifiers

PMID30562058
PMCPMC6459295
OpenAlexW2903878345

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.