Evidence map›Paper›PMID 30562054›Full record

ArticleAmerican journal of respiratory cell and molecular biology2019

Lung Adenocarcinoma Syndecan-2 Potentiates Cell Invasiveness.

Konstantin Tsoyi, Juan C Osorio, Sarah G Chu, Isis E Fernandez, Sergio Poli De Frias, Lynette Sholl, Ye Cui, Carmen S Tellez, Jill M Siegfried, Steven A Belinsky and 3 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
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  9. Article
  10. Review
  11. Article
  12. Article
  13. Proteoglycans as Mediators of Cancer Tissue Mechanics.Frontiers in cell and developmental biology · 2020
    Review
  14. Article
  15. Syndecan-2: Old Player in a New Field.American journal of respiratory cell and molecular biology · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Konstantin Tsoyi1 Division of Pulmonary and Critical Care Medicine, and.
Juan C Osorio1 Division of Pulmonary and Critical Care Medicine, and.
Sarah G Chu1 Division of Pulmonary and Critical Care Medicine, and.
Isis E Fernandez3 Comprehensive Pneumology Centre, Hospital of the Ludwig-Maximilians University of Munich, Munich, Germany.
Sergio Poli De Frias1 Division of Pulmonary and Critical Care Medicine, and.
Lynette Sholl4 Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Ye Cui1 Division of Pulmonary and Critical Care Medicine, and.
Carmen S Tellez5 Lung Cancer Program and.
Jill M Siegfried6 Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota.
Steven A Belinsky5 Lung Cancer Program and.
Mark A Perrella1 Division of Pulmonary and Critical Care Medicine, and.
Souheil El-Chemaly1 Division of Pulmonary and Critical Care Medicine, and.
Ivan O Rosas1 Division of Pulmonary and Critical Care Medicine, and.
Pulmonary and Critical Care Associates · USHarvard University · USLudwig-Maximilians-Universität München · DENew York Hospital Queens · USUniversity of Minnesota · US

Funding

Respiratory Computational Discovery CoreP01HL114501 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHOI, MARY E · 2013 to 2025
$24.9M
RESPIRATORY RESEARCHT32HL007633 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI George R Washko · 1985 to 2026
$14.9M
Lymphatics and Lung Allograft RejectionR01HL130275 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI EL-CHEMALY, SOUHEIL · 2016 to 2020
$2.2M
NHLBI NIH HHS P01 HL114501NHLBI NIH HHS R01 HL130275NHLBI NIH HHS T32 HL007633
6 · The paper itself

Abstract

Altered expression of syndecan-2 (SDC2), a heparan sulfate proteoglycan, has been associated with diverse types of human cancers. However, the mechanisms by which SDC2 may contribute to the pathobiology of lung adenocarcinoma have not been previously explored. SDC2 levels were measured in human lung adenocarcinoma samples and lung cancer tissue microarrays using immunohistochemistry and real-time PCR. To understand the role of SDC2

Indexed as

A549 CellsAdenocarcinoma of LungAnimalsCell NucleusCell ProliferationGene Expression Regulation, NeoplasticGene SilencingHumansLung NeoplasmsMatrix Metalloproteinase 9Mice, SCIDNeoplasm InvasivenessSyndecan-2SynteninsTranscription Factor RelAUp-RegulationMatrix Metalloproteinase 9SDC2 protein, humanSyndecan-2SynteninsTranscription Factor RelAlung adenocarcinomametastasissyndecan-2syntenin-1

Identifiers

PMID30562054
PMCPMC6543747
OpenAlexW2905381998

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.