ArticleChembiochem : a European journal of chemical biology2019
An Extended Approach for the Development of Fluorogenic trans-Cyclooctene-Tetrazine Cycloadditions.
Article in Chembiochem : a European journal of chemical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Organelle-Resolved Tetrazine-trans-Cyclooctene Click Chemistry for Cargo Delivery and Release.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Fluorescence Quenching Properties and Bioimaging Applications of Readily Accessible Blue to Far-Red Fluorogenic Triazinium Salts.Journal of the American Chemical Society · 2026Article
- Trans-cyclooctene-a Swiss army knife for bioorthogonal chemistry: exploring the synthesis, reactivity, and applications in biomedical breakthroughs.EJNMMI radiopharmacy and chemistry · 2024Review
- Advances in the Synthesis of Bioorthogonal Reagents: s-Tetrazines, 1,2,4-Triazines, Cyclooctynes, Heterocycloheptynes, and trans-Cyclooctenes.Topics in current chemistry (Cham) · 2024Review
- Recent Advances in Bioorthogonal Ligation and Bioconjugation.Topics in current chemistry (Cham) · 2023Review
- Versatile naphthalimide tetrazines for fluorogenic bioorthogonal labelling.RSC chemical biology · 2021Article
- Overview of Syntheses and Molecular-Design Strategies for Tetrazine-Based Fluorogenic Probes.Molecules (Basel, Switzerland) · 2021Review
- Tetrazine Carbon Nanotubes for Pretargeted In Vivo "Click-to-Release" Bioorthogonal Tumour Imaging.Angewandte Chemie (International ed. in English) · 2020Article
- A Systematic Study of Coumarin-Tetrazine Light-Up Probes for Bioorthogonal Fluorescence Imaging.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- Expanding the Scope of Antibody Rebridging with New Pyridazinedione-TCO Constructs.Bioconjugate chemistry · 2020Article
- Flow Photochemical Syntheses ofIsrael journal of chemistry · 2020Article
- Bioorthogonal Fluorescence Turn-On Labeling Based on Bicyclononyne-Tetrazine Cycloaddition Reactions that Form Pyridazine Products.ChemPlusChem · 2019Article
- An Extended Approach for the Development of Fluorogenic trans-Cyclooctene-Tetrazine Cycloadditions.Chembiochem : a European journal of chemical biology · 2019Article
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7 authors.
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Abstract
Inverse-electron-demand Diels-Alder (iEDDA) cycloaddition between 1,2,4,5-tetrazines and strained dienophiles belongs among the most popular bioconjugation reactions. In addition to its fast kinetics, this cycloaddition can be tailored to produce fluorescent products from non-fluorescent starting materials. Here we show that even the reaction intermediates formed in iEDDA cycloaddition can lead to the formation of new types of fluorophores. The influence of various substituents on their photophysical properties and the generality of the approach with use of various trans-cyclooctene derivatives were studied. Model bioimaging experiments demonstrate the application potential of fluorogenic iEDDA cycloaddition.
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