ReviewJournal of orthopaedic research : official publication of the Orthopaedic Research Society2019
Regenerative rehabilitation: The role of mechanotransduction in orthopaedic regenerative medicine.
Review in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Role of external forces in the mechanobiology of stem and differentiated chondrogenic cells embedded in a tissue-engineered construct for cartilage repair.Journal of biomedical science · 2026Review
- Mechanotransduction and its impact on regenerative medicine in orthopedic rehabilitation (Review).International journal of molecular medicine · 2026Review
- Melt Electrowriting High Resolution Poly(ethylene-co-vinyl acetate) Scaffolds for Soft Tissue Engineering.Advanced healthcare materials · 2026Article
- Convergent Regenerative Strategies in PM&R for Musculoskeletal and Hair Restoration: Integration of PRP, Exosomes, and Physical Modalities.Archives of internal medicine research · 2026Article
- Article
- Early mobilisation versus delayed protocols after reverse total shoulder arthroplasty for nonfracture indications: A systematic review and meta-analysis.Journal of experimental orthopaedics · 2025Review
- Strain energy in human tibia during different exercises with adjustable leg weights: a subject-specific computational model analysis.Medical & biological engineering & computing · 2025Article
- Combined regenerative rehabilitation improves recovery following volumetric muscle loss injury in a rat model.Journal of biomedical materials research. Part B, Applied biomaterials · 2024Article
- The Complementary Roles of Neurological and Musculoskeletal Physical Therapy and Regenerative Medicine: A Comprehensive Review.Medicina (Kaunas, Lithuania) · 2024Review
- Advances in regenerative rehabilitation in the rehabilitation of musculoskeletal injuries.Regenerative medicine · 2024Review
- Regulation of Oxygen Tension as a Strategy to Control Chondrocytic Phenotype for Cartilage Tissue Engineering and Regeneration.Bioengineering (Basel, Switzerland) · 2024Review
- Osteo-inductive effect of piezoelectric stimulation from the poly(l-lactic acid) scaffolds.PloS one · 2024Article
- Bioactive and Elastic Emulsion Electrospun DegraPol Tubes Delivering IGF-1 for Tendon Rupture Repair.International journal of molecular sciences · 2023Article
- Myths and truths on biophysics-based approach in rehabilitation of musculoskeletal disorders.Therapeutic advances in musculoskeletal disease · 2023Review
- ACL microtrauma: healing through nutrition, modified sports training, and increased recovery time.Journal of experimental orthopaedics · 2022Review
- Biophysical Modulation of Mesenchymal Stem Cell Differentiation in the Context of Skeletal Repair.International journal of molecular sciences · 2022Review
- Gene therapy for bone healing: lessons learned and new approaches.Translational research : the journal of laboratory and clinical medicine · 2021Review
- Mechanical Stress Inhibits Early Stages of Endogenous Cell Migration: A Pilot Study in an Ex Vivo Osteochondral Model.Polymers · 2020Article
- The Grand Challenges of Medical Technology.Frontiers in medical technology · 2020Article
- Current Trends in the Evaluation of Osteochondral Lesion Treatments: Histology, Histomorphometry, and Biomechanics in Preclinical Models.BioMed research international · 2019Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Regenerative rehabilitation is an emerging area of investigation that seeks to integrate regenerative medicine with rehabilitation medicine. It is based on the realization that combining these two areas of medicine at an early stage of treatment will produce a better clinical outcome than the traditional linear approach of first administering the elements of regeneration followed, after a delay, by rehabilitation. Indeed, in certain settings, a case can be made for initiating rehabilitation protocols before starting regenerative intervention. This review summarizes the contents of a workshop held during the 2018 annual meeting of the Orthopaedic Research Society. It introduced the concept of regenerative rehabilitation and then provided two orthopaedic examples drawn from the domains of cartilage repair and bone healing. Rehabilitation medicine can supply a variety of physical stimuli, including electrical stimulation, thermal stimulation and mechanical stimulation. Of these, mechanical stimulation has the most obvious relevance to orthopaedics. The mechano-responsiveness of cartilage and bone has been known for a long time, but is poorly understood and has led to only limited clinical application. Improved bioreactor designs that allow multi-axial loading enable new insights into the responsiveness of chondrocytes and chondroprogenitor cells to specific types of load, especially shear. Recent studies on the mechanobiology of bone healing show that modulating the mechanical environment of an experimental osseous lesion by a process of "Reverse Dynamization" soon after injury considerably enhances healing. Future studies are needed to probe the molecular mechanisms responsible for these phenomena and to translate these findings into clinical practice. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:1263-1269, 2019.
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