Evidence map›Paper›PMID 30561795›Full record

ArticleCancer2019

Testing a biobehavioral model of fatigue before adjuvant therapy in women with breast cancer.

Julienne E Bower, Arash Asher, Deborah Garet, Laura Petersen, Patricia A Ganz, Michael R Irwin, Steve W Cole, Sara A Hurvitz, Catherine M Crespi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
6.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Adverse childhood events and mental health problems in cancer survivors: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
  2. Interventions for multidimensional aspects of breast cancer-related fatigue: a meta-analytic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Pooled it
  3. Trial
  4. Targeted self-management limits fatigue for women undergoing radiotherapy for early breast cancer: results from the ACTIVE randomised feasibility trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Trial
  5. Relationship between social support, physical symptoms, and depression in women with breast cancer and pain.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Trial
  6. Article
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  10. Biobehavioral correlates of multidimensional fatigue in men with prostate cancer: A secondary data analysis.European journal of oncology nursing : the official journal of European Oncology Nursing Society · 2025
    Observational
  11. Factors associated with fatigue in women with breast cancer before starting treatment: a cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  12. Article
  13. Article
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  15. Article
  16. Radiotherapy-induced fatigue in Palestinian breast cancer survivors.Health psychology and behavioral medicine · 2024
    Article
  17. Genetic variability of oxidative stress and DNA repair genes associated with pre-treatment cancer-related fatigue in women with breast cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Julienne E BowerDepartment of Psychology, University of California at Los Angeles, Los Angeles, California.
Arash AsherCedars-Sinai Medical Center, Samuel Oschin Comprehensive Cancer Institute, Los Angeles, California.
Deborah GaretNorman Cousins Center for Psychoneuroimmunology, University of California at Los Angeles, Los Angeles, California.
Laura PetersenJonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, California.
Patricia A GanzJonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, California.
Michael R IrwinDepartment of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, Los Angeles, California.
Steve W ColeDepartment of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, Los Angeles, California.
Sara A HurvitzDepartment of Medicine, University of California at Los Angeles, Los Angeles, California.
Catherine M CrespiJonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, California.
University of California, Los Angeles · USCedars-Sinai Medical Center · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
Biobehavioral predictors of fatigue in newly-diagnosed breast cancer patientsR01CA160427 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOWER, JULIENNE E · 2012 to 2016
$3.2M
NCI NIH HHS P30 CA016042NCI NIH HHS R01 CA160427
6 · The paper itself

Abstract

backgroundFatigue is one of the most common and disabling side effects of cancer and its treatment. Although research typically has focused on fatigue that occurs during and after treatment, patients may experience fatigue even before treatment onset. The current study was designed to identify biobehavioral risk factors associated with fatigue before adjuvant therapy in women with early-stage breast cancer.

methodsPatients with stage 0 to stage IIIA breast cancer (270 women) were recruited before the onset of adjuvant or neoadjuvant therapy with radiotherapy, chemotherapy, and/or endocrine therapy. Host factors that may influence fatigue were identified from an empirically based, biobehavioral model and assessed using self-report questionnaires, medical record review, and blood collection (for genetic data). Fatigue was assessed by questionnaire. Linear regression analyses were used to evaluate the association between host factors and dimensions of fatigue, with general fatigue as the primary dimension of interest.

resultsFatigue was elevated at the pretreatment assessment compared with published controls. Bivariate analyses identified demographic, cancer-related, and biobehavioral correlates of fatigue. In the multivariable model, predictors of general fatigue included younger age, lower educational level, lower cancer stage, and history of childhood maltreatment (all P values <.05), with the full model accounting for approximately 18.4% of the variance in fatigue. Secondary analyses identified common and specific predictors of emotional, mental, and physical dimensions of fatigue.

conclusionsAmong women who have not yet initiated treatment of breast cancer, demographic and psychosocial factors are associated with elevated fatigue and could be used to identify at-risk patients for early intervention.

Indexed as

Biobehavioral SciencesModels, StatisticalNeoadjuvant TherapyAdultAgedAged, 80 and overBreast NeoplasmsChemotherapy, AdjuvantDepressionFatigueFemaleFollow-Up StudiesHumansMiddle AgedPrognosisQuality of Lifebreast cancerchildhood adversitydepressionfatiguegenetichost factors

Identifiers

PMID30561795
PMCPMC6373488
OpenAlexW2904576258

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.