ArticleThe Journal of infectious diseases2019
Prevention of Influenza Hospitalization Among Adults in the United States, 2015-2016: Results From the US Hospitalized Adult Influenza Vaccine Effectiveness Network (HAIVEN).
Article in The Journal of infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 2 of them syntheses that pooled it.
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Who cites it
58 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Influenza vaccine effectiveness according to frailty status in adults aged ≥ 50 years: a systematic review and meta-analysis.BMC infectious diseases · 2026Pooled it
- Does repeated influenza vaccination attenuate effectiveness? A systematic review and meta-analysis.The Lancet. Respiratory medicine · 2023Pooled it
- A Retrospective Test-Negative Case-Control Study to Evaluate Influenza Vaccine Effectiveness in Preventing Hospitalizations in Children.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Trial
- Influenza vaccine effectiveness and disease burden in children and adolescents with sickle cell disease: 2012-2017.Pediatric blood & cancer · 2020Trial
- Disparities in Adult Influenza Vaccination in the United States: Analysis of 2023 BRFSS Data.Infectious diseases and therapy · 2026Article
- Article
- Severity of Clinical Presentation and Outcomes in Hospitalized Adult People With Influenza by Type and Subtype, United States-2017-2020.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Article
- Vaccine effectiveness against influenza-associated hospitalizations in adults with liver disease, 2015-2020: US Hospitalized Adult Influenza Vaccine Effectiveness Network (HAIVEN).Human vaccines & immunotherapeutics · 2025Article
- Human Metapneumovirus and Respiratory Syncytial Virus in Children: A Comparative Analysis.Pediatrics · 2025Article
- Vaccine-Preventable Conditions: Disparities in Hospitalizations Affecting Rural Communities in the Southeast United States.International journal of environmental research and public health · 2025Article
- Article
- Area-based Deprivation Indices and Healthcare-Associated Infections: A Narrative Review of Evidence.Current infectious disease reports · 2025Review
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- Article
- Attitudes, motivators, and barriers toward influenza vaccination for children: a study from a conflict-ridden country.Conflict and health · 2024Article
- Influenza vaccination allocation in tropical settings under constrained resources.medRxiv : the preprint server for health sciences · 2024Article
- Modeling the potential health impacts of delayed strain selection on influenza hospitalization and mortality with mRNA vaccines.Vaccine: X · 2023Article
- Prevalence and Clinical Outcomes of Respiratory Syncytial Virus vs Influenza in Adults Hospitalized With Acute Respiratory Illness From a Prospective Multicenter Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Age Differences in Comorbidities, Presenting Symptoms, and Outcomes of Influenza Illness Requiring Hospitalization: A Worldwide Perspective From the Global Influenza Hospital Surveillance Network.Open forum infectious diseases · 2023Article
- K-medoids clustering of hospital admission characteristics to classify severity of influenza virus infection.Influenza and other respiratory viruses · 2023Article
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Authors and funding
14 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundEvidence establishing effectiveness of influenza vaccination for prevention of severe illness is limited. The US Hospitalized Adult Influenza Vaccine Effectiveness Network (HAIVEN) is a multiyear test-negative case-control study initiated in 2015-2016 to estimate effectiveness of vaccine in preventing influenza hospitalization among adults.
methodsAdults aged ≥18 years admitted to 8 US hospitals with acute respiratory illness and testing positive for influenza by polymerase chain reaction were cases; those testing negative were controls. Vaccine effectiveness was estimated with logistic regression adjusting for age, comorbidities, and other confounding factors and stratified by frailty, 2-year vaccination history, and clinical presentation.
resultsWe analyzed data from 236 cases and 1231 controls; mean age was 58 years. More than 90% of patients had ≥1 comorbidity elevating risk of influenza complications. Fifty percent of cases and 70% of controls were vaccinated. Vaccination was 51% (95% confidence interval [CI], 29%-65%) and 53% (95% CI, 11%-76%) effective in preventing hospitalization due to influenza A(H1N1)pdm09 and influenza B virus infection, respectively. Vaccine was protective for all age groups.
conclusionsDuring the 2015-2016 US influenza A(H1N1)pdm09-predominant season, we found that vaccination halved the risk of influenza-association hospitalization among adults, most of whom were at increased risk of serious influenza complications due to comorbidity or age.
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