Evidence map›Paper›PMID 30561556›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2019

Uncertainties in Screening and Prevention of Group B Streptococcus Disease.

Kirsty Le Doare, Paul T Heath, Jane Plumb, Natalie A Owen, Peter Brocklehurst, Lucy C Chappell

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04059510 (opTImisation of Methods for a Human INfection Model for Group B Streptococcus), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04059510 unknown statusnot on this map

opTImisation of Methods for a Human INfection Model for Group B Streptococcus

TypeobservationalSponsorSt George's, University of LondonRan2019 to 2020Enrolled500ConditionsGroup B StreptococcusArmsrectovaginal swab, pregnancy test, Menstrual cup, Blood test, Focus group
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Group BJournal of Korean medical science · 2025
    Article
  5. Screening forBio-protocol · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Considerations for post-licensure group B streptococcus vaccine effectiveness studies.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2023
    Article
  10. Updates on Group BMicroorganisms · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Group B streptococcal disease in the mother and newborn-A review.European journal of obstetrics, gynecology, and reproductive biology · 2020
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Kirsty Le DoarePaediatric Infectious Disease Research Group & Vaccine Institute, St George's University of London, London, United Kingdom.
Paul T HeathPaediatric Infectious Disease Research Group & Vaccine Institute, St George's University of London, London, United Kingdom.
Jane PlumbGroup B Strep Support, London, United Kingdom.
Natalie A OwenScience, Research and Evidence, Department of Health and Social Care, London, United Kingdom.
Peter BrocklehurstBirmingham Clinical Trials Unit, University of Birmingham, London, United Kingdom.
Lucy C ChappellDepartment of Obstetrics, King's College London, London, United Kingdom.
St George's, University of London · GBCancer Research UK Clinical Trials Unit · GBDepartment of Health and Social Care · GBKing's College London · GB

Funding

Department of Health RP-2014-05-019Medical Research Council MR/S016570/1
6 · The paper itself

Abstract

In autumn 2016, the UK Department of Health (now Department of Health and Social Care) convened 2 meetings to discuss how to address research evidence gaps in order to minimize the impact of infant group B streptococcus (GBS) disease in the United Kingdom. At that meeting, a number of research priorities were highlighted, including improving the screening for GBS colonization in pregnant women, offering intrapartum antibiotic prophylaxis and point-of-care testing, and understanding the effect of widespread intrapartum antibiotic use on long-term infant health. Further discussions involved investigating the feasibility of a large prospective study of pregnant women and their infants in order to understand the role of antibodies in the protection against GBS disease in infancy following maternal exposure to GBS colonization. Here, we summarize the research uncertainties identified at that meeting.

Indexed as

Pregnancy Complications, InfectiousStreptococcal InfectionsStreptococcus agalactiaeAnti-Bacterial AgentsAntibiotic ProphylaxisCarrier StateFemaleHumansInfant, NewbornInfectious Disease Transmission, VerticalPregnancyUnited KingdomAnti-Bacterial Agentsgroup B streptococcusmaternalneonatalscreeningvaccine

Identifiers

PMID30561556
PMCPMC6669315
OpenAlexW2903939013

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.