ArticleCerebral cortex (New York, N.Y. : 1991)2019
The Effect of Onset Age of Visual Deprivation on Visual Cortex Surface Area Across-Species.
Article in Cerebral cortex (New York, N.Y. : 1991), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Blindness reveals that Heschl's gyrus folding is not altered by auditory experience.bioRxiv : the preprint server for biology · 2026Article
- The temporal onset of associations of cortical proteins with cognitive resilience vary during late life.Neurobiology of disease · 2025Article
- Loss of Postnatal Retinal Input Perturbs Cortical Lamination in the Developing Ferret Visual Cortex.The Journal of comparative neurology · 2025Article
- Effects of early monocular enucleation on cortical spreading depression in well-nourished and malnourished adult rats.Experimental brain research · 2024Article
- A unified model for cross-modal plasticity and skill acquisition.Frontiers in neuroscience · 2024Review
- Brain structural plasticity in rats subjected to early binocular enucleation characterized by high resolution anatomical magnetic resonance imaging and diffusion tensor imaging.Magnetic resonance letters · 2023Article
- The retrocalcarine sulcus maps different retinotopic representations in macaques and humans.Brain structure & function · 2022Article
- Grey Matter Hypertrophy and Atrophy in Early-Blind Adolescents: A Surface-Based Morphometric Study.Disease markers · 2022Article
- Closing the gap from transcription to the structural connectome enhances the study of connections in the human brain.Developmental dynamics : an official publication of the American Association of Anatomists · 2020Review
- Multi-electrode stimulation evokes consistent spatial patterns of phosphenes and improves phosphene mapping in blind subjects.Brain stimulationArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Blindness early in life induces permanent alterations in brain anatomy, including reduced surface area of primary visual cortex (V1). Bilateral enucleation early in development causes greater reductions in primary visual cortex surface area than at later times. However, the time at which cortical surface area expansion is no longer sensitive to enucleation is not clearly established, despite being an important milestone for cortical development. Using histological and MRI techniques, we investigated how reductions in the surface area of V1 depends on the timing of blindness onset in rats, ferrets and humans. To compare data across species, we translated ages of all species to a common neuro-developmental event-time (ET) scale. Consistently, blindness during early cortical expansion induced large (~40%) reductions in V1 surface area, in rats and ferrets, while blindness occurring later had diminishing effects. Longitudinal measurements on ferrets confirmed that early enucleation disrupted cortical expansion, rather than inducing enhanced pruning. We modeled the ET associated with the conclusion of the effect of blindness on surface area at maturity (ETc), relative to the normal conclusion of visual cortex surface area expansion, (ETdev). A final analysis combining our data with extant published data confirmed that ETc occurred well before ETdev.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.