ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2019
Coprescribing of Benzodiazepines and Opioids in Older Adults: Rates, Correlates, and National Trends.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 60 citations in OpenAlex.
- Substance use patterns in a community sample of adult women in the United States: Alcohol, Cannabis, and other drug use.Addictive behaviors reports · 2026Article
- The impact of opioid prescribing guidelines on opioid dispensation: A systematic review and meta-analysis.Canadian journal of pain = Revue canadienne de la douleur · 2026Review
- Association of opioid and benzodiazepine coprescribing with adverse events among older adults with cancer.Journal of the National Cancer Institute · 2025Article
- Concurrent Prescribing of Opioids and Sedative-Hypnotic Drugs for Long-Term Use in Australian General Practice: A Cross-Sectional Analysis Using MedicineInsight.Pharmacology research & perspectives · 2025Article
- Development of the barriers to opioid access scale among individuals with chronic pain.Exploratory research in clinical and social pharmacy · 2025Article
- Individual and prescription level factors associated with overdose in opioid naïve older people.Journal of the American Geriatrics Society · 2025Article
- Article
- The burden of acute pain in the U.S. in the wake of the opioid crisis.Frontiers in pain research (Lausanne, Switzerland) · 2025Review
- The association of prescriber prominence in a shared-patient physician network with their patients receipt of and transitions between risky drug combinations.Applied network science · 2025Article
- A scoping review of motor vehicle operator performance assessments for benzodiazepine receptor agonists.Exploratory research in clinical and social pharmacy · 2024Article
- Exploiting relationship directionality to enhance statistical modeling of peer-influence across social networks.Statistics in medicine · 2024Article
- Pharmacist-Led Deprescribing of Opioids and Benzodiazepines in Older Adults: Examining Implementation and Perceptions.Pharmacy (Basel, Switzerland) · 2024Article
- Association between Opioid-Benzodiazepine Trajectories and Injurious Fall Risk among US Medicare Beneficiaries.Journal of clinical medicine · 2024Article
- Association Between Opioid and Benzodiazepine Use and All-Cause Mortality in Individuals with Chronic Obstructive Pulmonary Disease: A Prospective Cohort Study.International journal of chronic obstructive pulmonary disease · 2024Article
- Patient Perceptions of Opioids and Benzodiazepines and Attitudes Toward Deprescribing.Drugs & aging · 2023Article
- Health care system costs related to potentially inappropriate medication use involving opioids in older adults in Canada.BMC health services research · 2023Article
- Pain Management in Older Adults Before and During the First Year of COVID-19 Pandemic: Prevalence, Trends, and Correlates.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Considering pharmacoequity when deprescribing potentially inappropriate medications.Journal of the American Geriatrics Society · 2023Article
- Patterns and disparities in prescribing of opioids and benzodiazepines for older adults in North Carolina.Journal of the American Geriatrics Society · 2023Article
- An observational study of the factors associated with frequency of outpatient benzodiazepine prescribing to patients receiving chronic opioid analgesic therapy in primary care at a major academic center.BMC primary care · 2022Observational
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
backgroundTo estimate prescribing trends of and correlates independently associated with coprescribing of benzodiazepines and opioids among adults aged 65 years or older in office-based outpatient visits.
methodsI examined a nationally representative sample of office-based physician visits by older adults between 2006 and 2015 (n = 109,149 unweighted) using data from the National Ambulatory Medical Care Surveys (NAMCS). National rates and prescribing trends were estimated. Then, I used multivariable logistic regression analyses to identify demographic and clinical factors associated with coprescriptions of benzodiazepines and opioids.
resultsFrom 2006 to 2015, 15,954 (14.6%) out of 109,149 visits, representative of 39.3 million visits nationally, listed benzodiazepine, opioid, or both medications prescribed. The rate of prescription benzodiazepines only increased monotonically from 4.8% in 2006-2007 to 6.2% in 2014-2015 (p < .001), and the rate of prescription opioids only increased monotonically from 5.9% in 2006-2007 to 10.0% in 2014-2015 (p < .001). The coprescribing rate of benzodiazepines and opioids increased over time from 1.1% in 2006-2007 to 2.7% in 2014-2015 (p < .001). Correlates independently associated with a higher likelihood of both benzodiazepine and opioid prescriptions included: female sex, a visit for chronic care, receipt of six or more concomitantly prescribed medications, and clinical diagnoses of anxiety and pain (p < .01 for all).
conclusionThe coprescribing rate of benzodiazepines and opioids increased monotonically over time in outpatient care settings. Because couse of benzodiazepines and opioids is associated with medication burdens and potential harms, future research is needed to address medication safety in these vulnerable populations.
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