Observational studyAmerican journal of epidemiology2019
Causal Mediation Analysis With Observational Data: Considerations and Illustration Examining Mechanisms Linking Neighborhood Poverty to Adolescent Substance Use.
Observational study in American journal of epidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- The direct and urinary electrolyte-mediated effects of ambient temperature on population blood pressure: A causal mediation analysis.Environment international · 2025Trial
- Race and Ethnicity, Hypertension, and Neuroimaging Markers of Brain Aging: A Causal Mediation Analysis in the HABS-HD Study.Neurology · 2026Article
- A Causal Framework for Evaluating the Total Effect of Strategies Aiming to Expand Screening and to Improve Outcomes.Statistics in medicine · 2026Article
- Neighborhood Deprivation and Adolescent Mental Health: The Protective Role of School Staffing Patterns.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Article
- Article
- Causal Mediation Analysis for Effect Heterogeneity.Observational studies · 2026Article
- From toxicogenomics to predictive toxicology and exposomics: defining the next decade of gene-environment research.Frontiers in genetics · 2026Article
- Article
- Factors Associated with Substance Use Disorder among High-Need Adolescents and Young Adults in North Carolina.North Carolina medical journal · 2024Article
- Invited Perspective: Opportunities and Obstacles of Longitudinal Data in Pregnancy to Quantify Mechanisms and Understand Etiology.Environmental health perspectives · 2023Article
- Direct Effect of Life-Course Socioeconomic Status on Late-Life Cognition and Cognitive Decline in the Rush Memory and Aging Project.American journal of epidemiology · 2023Article
- Does Neighborhood Crime Mediate the Relationship Between Neighborhood Socioeconomic Status and Birth Outcomes? An Application of the Mediational G-Formula.American journal of epidemiology · 2023Article
- Effect of Carnitine Supplementation in Pediatric Patients with Left Ventricular Dysfunction.Pediatric cardiology · 2023Article
- Dysregulated Emotion and Trying Substances in Childhood: Insights from a Large Nationally Representative Cohort Study.Substance use & misuse · 2023Article
- Article
- Article
- Air pollution, children's academic achievement and the potential mediating role of preterm birth.International journal of hygiene and environmental health · 2022Article
- Mediation analysis methods used in observational research: a scoping review and recommendations.BMC medical research methodology · 2021Article
- Article
- The Peril of Power: A Tutorial on Using Simulation to Better Understand When and How We Can Estimate Mediating Effects.American journal of epidemiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Understanding the mediation mechanisms by which an exposure or intervention affects an outcome can provide a look into what has been called a "black box" of many epidemiologic associations, thereby providing further evidence of a relationship and possible points of intervention. Rapid methodologic developments in mediation analyses mean that there are a growing number of approaches for researchers to consider, each with its own set of assumptions, advantages, and disadvantages. This has understandably resulted in some confusion among applied researchers. Here, we provide a brief overview of the mediation methods available and discuss points for consideration when choosing a method. We provide an in-depth explication of 2 of the many potential estimators for illustrative purposes: the Baron and Kenny mediation approach, because it is the most commonly used, and a recently developed approach for estimating stochastic direct and indirect effects, because it relies on far fewer assumptions. We illustrate the decision process and analytical procedure by estimating potential school- and peer-based mechanisms linking neighborhood poverty to adolescent substance use in the National Comorbidity Survey Adolescent Supplement.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.